Antibodies for providing protection against P. vivax malaria inf

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530808, 530809, 5303887, 5303872, 424 858, 435 702, 435 7021, 4351722, 935 89, 935 95, 935106, 935107, 935108, C07K 1528, C12N 512

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051010178

ABSTRACT:
A monoclonal antibody which identifies the human blood group Duffy (ab) is provided. Such monoclonal antibody blocks the penetration of P. vivax malaria parasite into human red blood cells by virtue of effective blocking of the target molecule of the P. vivax malaria parasite. Such monoclonal antibody has a combining site having the same stereochemistry as the ligand site on P. vivax, and elicits anti-idiotypic antibodies that react with the parasite.

REFERENCES:
patent: 4466917 (1984-08-01), Nussenzweig et al.
Vernes et al., Am. J. Trop. Med. Hyg., 33(2), 1984, pp. 197-203.
Davies et al., Transfusion, 1979, vol. 9(5), p. 638.
Miller et al., Science 234, 1986, pp. 1349-1356.
Hadley et al., Science 223, 1984, pp. 597-599.
Moore et al., Nature 295, 1982, pp. 529-531.
Tharavanig, Southeast Asian J. Trop. Med. Pub. Health, 16, 1985, pp. 314-331.
Seuier et al., Clin. Chemistry 27(11), 1981, pp. 1797-1806.
Hollingdale et al., J. Immunol. 132, 1984, pp. 909-913.
A. C. Allison, "Polymorphism and Natural Selection in Human Populations", Cold-Spring Harbor Sympos., Quant. Biol., 29, 137 (1964).
M. J. Friedman, "Oxidant Damage Mediates Variant Red Cell Resistance to Malaria", Nature, 280, 245 (1979).
F. B. Livingston, "The Duffy Blood Groups, Vivax Malaria and Malaria Sections in Human Populations: Review", Human Biol., 56, 413 (1984).
L. H. Miller, H. J. Mason, D. F. Clyde and M. H. McGinnis, "The Resistance Factor to Plasmodium vivax in Blacks, The Duffy Blood Group Genotype (a-b-)", N. Engl. J. Med., 295, 302 (1976).
M. Hommel, "Antigenic Variation in Malaria Parasites", Immunology Today, 6, 28 (1985).
F. Zavala, A. Masuda, P. M. Graves, V. Nussenzweig and R. Nussenzweig, "Ubiquitey of the Repetitive Epitope of the CS Protein in Different Isolates of Human Malaria Parasites", J. Immunol., 135, 2790 (1985).
M. Hommel, P. H. David and L. D. Oligino, "Surface Alterations of Erythrocytes in Plasmodium falciparum Malaria. I. Antigenic Variation, Antigenic Diversity and the Role of the Spleen", J. Exp. Med., 157, 1137 (1983).
R. J. Howard, J. W. Barnwell and V. Kao, "Antigenic Variation in Plasmodium knowlesi Malaria: Identification of the Variant Antigen on Infected Erythrocytes", Proc. Natl. Acad. Sci., USA, 80, 4129 (1983).
R. S. Nussenzweig and V. Nussenzweig, "Development of Sporozoite Vaccines", Philos. Trans. R. Soc. Lond (Biol), 307, 117 (1984).
D. R. Spriggs, "The Malaria Sporozoite Vaccine", Parasitology's Brave New World, J. Infect. Dis., 152, 655 (1985).
H. C. Spencer, L. H. Miller, W. E. Collins et al., "The Duffy Blood Group and Resistance to Plasmodium vivax in Honduras", Am. J. Trop. Med. Hyg., 27, 664 (1978).

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