Antibodies for penicilloic acid their preparation and use

Details Antibodies for penicilloic acid their preparation and use Antibodies for penicilloic acid their preparation and use

1983-11-02

1986-06-24

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 88, 435 4, 435 18, 435 28, 435177, 435188, 435805, 435810, 436530, 436543, 436544, 436547, 436810, 436815, 436822, 436823, 530405, 530364, 530388, 530807, G01N 3353, C07K 1506, A61K 3900, C12Q 100

Patent

active

045967687

ABSTRACT:
Conjugates of penicilloic acid derivatives and certain poly(amino acids), which are either antigenic or enzymatic, are provided. Antibodies raised against the antigenic poly(amino acids) and the enzyme conjugates are used as reagents in immunoassays. In particular, the compounds of the present invention can be used for measuring the presence of a .beta.-lactamase in a patient serum sample by adding a known amount of penicillin to the sample and observing the production of penicilloic acid over a fixed period of time.

REFERENCES:
patent: 4234683 (1980-11-01), McMillan
patent: 4347312 (1982-08-01), Brown et al.
Vunakis et al., Methods in Enzymology, vol. 70, "Immunochemical Techniques", 1980, Academic Press, New York, pp. 85-104.
Kitagawa et al., "A New Method for Preparation of an Antiserum to Penicillin and Its Application for Novel Enzyme Immunoassay of Penicillin," J. Biochem., vol. 84, No. 2, (1978) pp. 491-494.
Horiuchi et al. "Int. Arch. Allergy", 28:306-320 (1965).
Yolken et al., "J. of Pediatrics", vol. 97, No. 5, pp. 715-720 (1980).

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