Antibodies for P-glycoprotein encoded by the mdr1 gene and uses

Details Antibodies for P-glycoprotein encoded by the mdr1 gene and uses Antibodies for P-glycoprotein encoded by the mdr1 gene and uses

1992-04-17

1994-11-29

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435243, 43524027, 424 9, 424 149, 5303877, 5303888, G01N 33574, G01N 3353, C12N 512, C07K 1528

Patent

active

053690095

ABSTRACT:
A novel antibody capable of binding to a 170,000 dalton P-glycoprotein encoded by the mdr1 gene, wherein said antibody binds to an external epitope on the protein and does not substantially increase the intracellular accumulaton or the cytoxicity of either Daunomycin or vinblastine in multidrug resistant cells is described. Methods of use of such antibodies are also described.

REFERENCES:
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Areci, R. J., et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., vol. 33, A2815, 1992.
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