Antibodies for norovirus

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...

Reexamination Certificate

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C435S975000, C435S339000

Reexamination Certificate

active

08066998

ABSTRACT:
Norovirus antigen peptides are described having an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-16, or fragments thereof. Such peptides can be used in the preparation of antiviral therapies such as vaccines, methods of preparing antibodies to the antigen peptides, methods of using the peptides or the corresponding antibodies for detection of norovirus, and compositions of the peptides, DNA and/or antibodies. A kit for the detection of norovirus is also provided.

REFERENCES:
patent: 02/19986 (2002-03-01), None
patent: 2005/030806 (2005-04-01), None
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Torche et al. Vet. immunol. Immunopathol. 2006, vol. 109, No. 3-4, pp. 209-217.
Vance P. Lochridge, et al; “Epitopes in the P2 domain of norovirus VP1 recognized by monoclonal antibodies that block cell interactions”, Journal of General Virology (2005), 86, pp. 2799-2806.
Tracy Dewese Parker, et al; “Identification of Genogroup I and Genogroup II Broadly Reactive Epitopes on the Norovirus Capsid”, Journal of Virology, Jun. 2005, pp. 7402-7409, vol. 79, No. 12.
Tomoko Yoda, et al; “Precise Characterization of Norovirus (Norwalk-Like Virus)-Specific Monoclonal Antibodies with Broad Reactivity”, Journal of Clinical Microbiology, Jun. 2003, pp. 2367-2371, vol. 41, No. 6.
Tomoyuki Shiota, et al; “Characterization of a Broadly Reactive Monoclonal Antibody against Norovirus Genogroups I and II: Recognition of a Novel Conformational Epitope”, Journal of Virology, Nov. 2007, pp. 12298-12306, vol. 81, No. 22.

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