Antibodies for mevalonic acid and methods for immunological dete

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303898, 43524027, C07K 1606, C07K 1618

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active

054709563

ABSTRACT:
Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.

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Bolton et al., "Radioimmunology and Related Methods" Handbook of Experimental Immunology, Weir (Ed.), Blackwell Scientific Publications, pp. 26.1-26.56, (1986).
Goding, Journal of Immunological Methods, vol. 39, pp. 285-308 (1980).
J. Clin. Invest,, 74, 795 (1984), Thomas S. Parker et al., "Plasma Mevalonate as a Measure of Cholesterol Synthesis in Man".
Enzyme Immunoassay, 2nd Edition, Eiji Ishikawa et al. (Eds), published by Igaku Shoin, Japan, pp. 82-126 (1982).

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