Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-03-10
1999-11-16
Spector, Lorraine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 536 235, 435 691, C07K 1628
Patent
active
059860650
ABSTRACT:
The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
REFERENCES:
patent: 5216132 (1993-06-01), Basi
patent: 5223427 (1993-06-01), Edgington
patent: 5552300 (1996-09-01), Makrides et al.
Rao et al., Thrombosis Research 56: 109-118, 1989.
Fiore et al., Blood 80(12):3127-34, Dec. 1992.
Clarke et al., The Journal of Immunology 145:2286-96, 1990.
Ragni et al., Circulation 93: 1913-1918, May 1996.
S. Ward, Communications, pp. 885-890 (1992).
C. Schlueter et al., J. Mol. Biol. 256:859-869 (1996).
George et al., Macromolecular sequencing and synthesis, Alan Riss, pp. 127-149, 1988.
Groves et al., Hybridoma 6(1):71-76, 1987.
Illustrated Dictionary of Immunology, Cruse et al., CRC Press, 1995.
Morrison, Ann.Rev.Immunol. 10:239-65, 1992.
T. Onda et al., Molecular Immunology, 32 (17-18) :1387-1397 (1995).
J. Novotny et al., Proc. Natl. Acad. Sci. USA, 88:8646-8650 (1991).
C. Wulfing et al., J. Mol. Biol., 242:655-669 (1994).
I. Kurcz et al., Proc. Natl. Acad. Sci. USA, 90:3830-3384 (1993).
S. Parmley et al., Gene, 73:305-318 (1988).
G. Smith et al., Methods in Enzymology, 217:228-257 (1993).
C. Chothia et al., The EMBO Journal, 7(12):3745-3755 (1988).
W. Soo Hoo et al., Proc. Natl. Sci. USA, 89:4759-4763 (1992).
E. Ward, Scand. J. Immunol, 34:215-220 (1991).
A. Lin et al., Science, 249:677-679 (1990).
C. Gregoire et al., Proc. Natl. Acad. Sci. USA, 88:8077-8081 (1991).
N. Gasciogne et al., Proc. Natl. Acad. Sci. USA, 84:2936-2940 (1987).
R. Mariuzza et al., The Journal of Biological, 264(13):7310-7316 (1989).
J. Kappler et al., Proc. Natl. Acad. Sci. USA, 91:8462-8466 (1994).
Jiao Jin-An
Luepschen Lawrence
Nieves Esperanza Liliana
Wong Hing C.
Buchanan Robert L.
Corless Peter F.
Lazar-Wesley Eliane
Spector Lorraine
Sunol Molecular Corporation
LandOfFree
Antibodies for inhibiting blood coagulation and methods of use t does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies for inhibiting blood coagulation and methods of use t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies for inhibiting blood coagulation and methods of use t will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1326314