Antibodies for identifying and/or isolating at least one...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S343000, C435S070210, C530S388100, C530S388220

Reexamination Certificate

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07741114

ABSTRACT:
Monoclonal antibodies, or fragments thereof, are used for isolating and/or identifying at least one cell population. The cell population can include any of the following types of cells: haematopoietic stem cells, neuronal stem cells, neuronal progenitor cells, mesenchymal stem cells and mesenchymal progenitor cells. The antibodies, or fragments thereof, bind to an antigen which is the same as that bound by an antibody which is produced by the hybridoma cell lines CUB1, CUB2, CUB3 and CUB4, which were deposited in the DSMZ under the numbers DSM ACC2569, DSM ACC2566 and DSM ACC2565, on 14 Aug. 2002, and DSM ACC2551, on 12 Jul. 2002.

REFERENCES:
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patent: WO 00/06698 (2000-02-01), None
patent: WO 01/40466 (2001-06-01), None
patent: WO 01/54477 (2001-08-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 02/04508 (2002-01-01), None
Hooper et al., Oncogene, Mar. 27, 2003;22(12):1783-1794.
Cassett, F. et al. 2003 “A peptide mimetic of an anti-CD4 monoclonal antibody by rational design”Biochem and Biophys Res Comm307:198-205.
Conze, T. et al. 2003 “CDCP1 is a novel marker for hematopoetic stem cells”Ann N.Y. Acad Sci996:222-226.
Rudikoff, S. et al. 1982 “Single Amino acid substitution altering antigen-binding specificity” ProcNatl Acad Sci USA79:1979-1983.
Scherl-Mostageer, M. et al. 2001 “Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer”Oncogene20:4402-4408.
Yin, A.H. et al. 1997 “AC133, a novel marker for human hematopoietic stem cell and progenitor cells”Blood90:5002-5012.

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