Antibodies for human phospholipase inhibitory protein (hPIP)

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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Details

53038826, 5303891, 5303871, C07K 1600, C07K 1640

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active

056462549

ABSTRACT:
Antibodies which react with the human phospholipase inhibitory protein/apolipoprotein AIV complex and hPIP are provided.

REFERENCES:
patent: 5264550 (1993-11-01), Johnson et al.
Hong et al., "Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids" Proc. Natl. Acad. Sci. USA (1976) 73(5):1730-1734.
Hirata, F., "The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation" J. Biol. Chem. (1981) 256(15):7730-7733.
Blackwell et al., "Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids" Nature (1980) 287:147-149.
Russo-Marie et al., "Dexamethasone-induced inhibition of prostaglandin production does not result from a direct action on phospholipase activities but is mediated through a steroid-inducible factor" Biochim. Biophys. Acta (1982) 712:177-185.
Hirata et al., "A phospholipase A.sub.2 inhibitory protein in rabbit neutrophils induced by glucocorticoids" Proc. Natl. Acad. Sci. USA (1980) 77(5):2533-2536.
Rothhut et al., "Further characterization of the gucocorticoid-induced antiphospholipase protein renocortin" Biochem. Biophys. Res. Commun. (1983) 117(3):878-884.
Hirata et al., "Identification of several species of phospholipase inhibitory protein(s) by radioimmunoassay for lipomodulin" Biochem. Biophys. Res. Commun. (1982) 109(1):223-230.
Johnson et al., "Glucocorticoid action: a mechanism involving nuclear and non-nuclear pathways" Brit. J. Dermatol. (1982) 107(Suppl23):6-23.
Hattori et al., "Differentiation of a histiocytic lymphoma cell line by lipomodulin, a phospholipase inhibitory protein" Biochem. Biophys. Res. Commun. (1983) 111(2):551-559.
Errasfa et al., "The presence of lipocortin in human embryonic skin fibroblasts and its regulation by anti-inflammatory steroids" Biochim. Biophys. Acta. (1985) 847:247-254.
Wallner et al., "Cloning and expression of human lipocortin, a phospholipase A.sub.2 inhibitor with potential anti-inflammatory activity" Nature (1986) 320:77-81.
Pepinski et al., "Purification and Partial sequence analysis of a 37-kDa protein that inhibits phospholipase A.sub.2 activity from rat peritoneal exudates" J. Biol. Chem. (1986) 261:4239-4261.

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