Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1999-02-16
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303882, 53038822, 53038826, 53038885, 5303891, C07K 1618, C07K 1628, C07K 1640
Patent
active
058722190
ABSTRACT:
A new substrate of epidermal growth factor receptor and certain other tyrosine kinase receptors denominated eps15, polynucleotides encoding eps15, antisense eps15 polynucleotide, triple helix eps15 polynucleotide, antibodies to eps15, and assays for determining eps15.
REFERENCES:
patent: 4543439 (1985-09-01), Frackelton
Aaronson, Stuart A., (1991) Growth Factors and Cancer. Science 254:1146-1153.
Bairoch, Amos. (1992). Prosite: a dictionary of sites and patterns in proteins. Nucleic Acids Res. 20:2013-2018.
Bernard, O., et al., (1994) A novel gene, AF-1p. fused to HRX in t(1:11)(p32:q23). is not related to AF-4, AF-9 nor ENL. Oncogene 9:1039-1045.
Coughlin, Shaun R. et al., (1989) Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science 243:1191-1194.
DiFiore, Pier P. et al., (1987) Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell 51:1063-1070.
Difiore, Pier P. et al., (1990) The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity. Mol. Cell. Bio. 10:2749-2756.
DiFiore, Pier P. et al., (1990) EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling. Science 248:79-83.
Escobedo, Jaime A. et al., (1991) cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGF .beta.-receptor. Cell 65:75-82.
Fazioli, F. et al., (1992) Identification and biochemical characterization of novel putative substrates for the epidermal growth factor receptor kinase*. J. Biol. Chem. 267:5155-5161.
Fazioli, F. et al., (1991) The erbB-2 mitogenic signaling pathway: Tyrosine phosphorylation of phospholipase C-.gamma. and GTPase-activating protein does not correlate with erbB-2 mitogenic potency. Mol. Cell. Biol. 11:2040-2048.
Fazioli, F. et al., (1993) The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene 8:1335-1345.
Felgner, P. L. et al. (1991) Gene therapeutics. Nature 349:351-352.
Giard, Donald J. et al., (1973) In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors. J. Nat'l Cancer Institute 51:1417-1423.
Gould, Kathleen L. et al., (1988) Platelet-derived growth factor induces multisite phosphorylation of pp60.sup.c-src and increases its protein-tyrosine kinase activity. Mol. Cell. Bio. 8:3345-3356.
Green, Pamela J. et al., (1986) The role of antisense RNA in gene regulation. Ann. Rev. Biochem. 55:569-597.
Griffin, Linda C. et al., (1989) Recognition of thymine-adenine base pairs by guanine in a pyrimidine triple helix motif. Science 245:967-971.
Heizmann et al., (1991) Intracellular calcium-binding proteins: more sites than insights. Trends Biochem. Sci. 16:98-103.
Helene, C., (1991) The anit-gene strategy: control of gene expression by triplex-forming-oblionucleotides. Anti-Cancer Drug Design 6:569-584.
Hunter, Tony. (1982) Synthetic peptide substrates for a tyrosine protein kinase*. J. Bio. Chem. 257:4843-4848.
Kaplan, David R. et al., (1990) PDGF .beta.-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell 61:125-133.
Kazlauskas, Andrius et al., (1989) Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell 58:1121-1133.
Kazlauskas, Andrius et al., (1990) Binding of GAP to activated PDGF receptors. Science 247:1578-1581.
Kirkness, Ewen F. et al., (1991) Isolation, characterization, and localization of human genomic DNA encoding the .beta.1 subunit of the GABA.sub.A receptor (GABRB1). Genomics 10:985-995.
Koch, C. Anne et al., (1991) SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins. Science 252:668-674.
Koerner, T.J. et al., (1991) High-expression vectors with multiple cloning sites for constructin of trpE fusion genes: pATH vectors. Methods Enzymol. 194:477-490.
Kozak, Marilyn, (1989) The scanning model for translation: An update. J. Cell. Biol. 108:229-241.
Kraus, M.H. et al., (1991). Detection and isolation of novel protein-tyrosine kinase genes employing reduced stringency hybridization. Methods Enzymol. 200:546-556.
Kypta, Robert M. et al., (1990) Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62:481-492.
Lee, James et al., (1989) HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor. EMBO J 8:167-173.
Lehvaslaiho, Heikki et al., (1989) A chimeric EGF-R--neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell tranformation. EMBO J. 8-159-166.
Lonardo, Fulvio et al., (1990) The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. New Biol. 2:992-1003.
Margolis, B. et al., (1989) EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling. Cell 57:1101-1107.
McCombie, W. Richard et al., (1991) The use of exonuclease III deletions in automated DNA sequencing. Methods 3:33-40.
McLachlan, Andrew D. et al., (1983) Periodic features in the amino acid sequence of nematode myosin rod. J. Mol. Bio. 164:605-626.
Meisenhelder, Jill et al., (1989) Phospholipase C-.gamma. is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell 57:1109-1122.
Molloy, Christopher J. et al., (1989) PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature 342:711-713.
Morrison, Deborah K. et al., (1988) Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF .beta.-receptor. Cell 58:649:657.
Morrison, Deborah K. et al., (1989) Signal transduction from membrane to cytoplasm: Growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc. Natl. Acad. Sco. USA 85:8855-8859.
Otsu, Masayuki et al., (1991) Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60.sup.c-src complexes and P13 kinase. Cell 65:91-104.
Rossi, John J. et al., (1991) The potential use of catalytic RNAs in therapy of HIV infection and other diseases. Pharm. Ther. 50:245-254.
Ruderman, Neil B. et al., (1990) Activation of phosphatidylinositol 3-kinase by insulin. Proc. Natl. Acad. Sci. USA 87:1411-1415.
Segatto, Oreste et al., (1991) The juxtamembrane regions of the epidermal growth factor receptor and gpl85.sup.erbB-2 determine the specificity of signal transduction. Mol. Cell. Biol. 11:3191-3202.
Skolnik, E.Y. et al., (1991) Cloning of P13 kinase--Associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83-90.
Ullrich, Axel et al., (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
Varticovski, Lyuba et al., (1989) The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature 342:699-702.
Wahl, Matthew I. et al., (1989) Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase c-.gamma. in quiescent BALB/c 3T3 cells. Mol. Cell. Biol. 9:2934-2943.
Wolff, Jon A. et al., (1990) Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
Wong, William et al., (1994) The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. Oncogene 9:1591-1597.
Fazioli, F., et al., (1993) eps15, A Novel Tyrosine Kinase Substrate, Exhibits Transforming Activity, Molecular Cellular Biology 13:5814-5828.
DiFiore Pier Paolo
Fazioli Francesca
Johnson Nancy A.
Scheiner Toni R.
The United States of America as represented by the Department o
LandOfFree
Antibodies drawn to the eps15 substrate for epidermal growth fac does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies drawn to the eps15 substrate for epidermal growth fac, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies drawn to the eps15 substrate for epidermal growth fac will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2063270