Antibodies directed towards a novel human EP prostaglandin...

Details Antibodies directed towards a novel human EP prostaglandin... Antibodies directed towards a novel human EP prostaglandin...

2005-06-28

2005-06-28

Landsman, Robert (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S388100, C530S388220

Reexamination Certificate

active

06911531

ABSTRACT:
A gene encoding the HP4 human prostaglandin receptor is disclosed. The protein encoded by this gene exhibits significant sequence identity with other prostaglandin receptors. The HP4 receptor, when expressed in eukaryotic cells, is capable of binding prostaglandins and their analogs and stimulating adenylate cyclase activity in response to prostaglandins. Also disclosed are antisense agents able to decrease or prevent translation of a human HP4 prostaglandin receptor.

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Colwell DE, et al. Methods in Enzymology. 121:42-51, 1986.
Honda et al, “Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype”, J. Biol. Chem. 268: 7759-7762, 1993.
Katsuyama et al, FEBS Letters, vol. 344, p. 74, 1994.

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