Antibodies directed to PDGFD and uses thereof

Details Antibodies directed to PDGFD and uses thereof Antibodies directed to PDGFD and uses thereof

2006-11-14

2006-11-14

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S133100, C424S145100, C530S387100, C530S387300, C530S388230

Reexamination Certificate

active

07135174

ABSTRACT:
The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4816397 (1989-03-01), Boss et al.
patent: 5151510 (1992-09-01), Stec et al.
patent: 5194594 (1993-03-01), Khawli et al.
patent: 5733743 (1998-03-01), Johnson et al.
patent: 5916771 (1999-06-01), Hori et al.
patent: 6207418 (2001-03-01), Hori et al.
patent: 6432673 (2002-08-01), Gao et al.
patent: 6468543 (2002-10-01), Gilbertson et al.
patent: 6495668 (2002-12-01), Gilbert et al.
patent: 6528050 (2003-03-01), Gao et al.
patent: 6630142 (2003-10-01), Hart et al.
patent: 6706687 (2004-03-01), Eriksson et al.
patent: 6814965 (2004-11-01), Gao et al.
patent: 6827938 (2004-12-01), Hart et al.
patent: 6866991 (2005-03-01), Gilbertson et al.
patent: 6887982 (2005-05-01), Gao et al.
patent: 6893637 (2005-05-01), Gilbertson
patent: 6962802 (2005-11-01), Gilbert et al.
patent: WO 94/29444 (1994-12-01), None
patent: WO 97/38137 (1997-10-01), None
patent: WO 01/25433 (2001-04-01), None
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Kuby et al., 1994, Immunology, second edition, pp. 85-96.
Janway et al, p. 3:1-3:3, in Immunobiology, 1994.
Merriam-Webster's Online Dictionary, 10th Edition.
Green et al, Nature Genetics 7: 13-21, May 4, 1994.
Alon et al.Nat. Med., 1(10):1024-1028 (1995).
Athanassiades et al.Placenta, 19(7): 465-473 (1998).
Baldrick,Regul. Toxicol. Pharmacol., 32(2):210-218 (2000).
Bellamy et al.Cancer Res., 59(3):728-733 (1999).
Blake et al.BioConjugate Chem., Abstract only, 3:510-513 (1992).
Bowie et al.Science, Abstract only, 253:164-170 (1991).
Carmeliet et al.Cell, 98(2):147-157 (1999).
Charman,J. Pharm. Sci., 89(8):967-978 (2000).
Chen et alHum. Gene Ther., Abstract only, 5(5):595-601 (1994).
Chiswell et al.Trends Biotechnol., Abstract only, 10(3):80-84 (1992).
Chothia et al.J. Mol. Biol., Abstract only, 196(4):901-917 (1987).
Chothia et al.Nature, 342:878-883 (1989).
Crossen et al.Cancer Genet. Cytogenet., 112:144-148 (1999).
Cwirla et al.Proc. Natl. Acad. Sci. USA, 87:6378-6382 (1990).
Deo et al.Immunol. Today, 18:127-135 (1997).
Evans et al.J. Med. Chem., Abstract only, 30(7):1229-1239 (1987).
Fanger et al.Immunomethods., Abstract only, 4(1):72-81 (1994).
Ferrara,Curr. Top Microbiol. Immunol., 237:1-30 (1999).
Ferti-Passantonopoulou et al.Cancer Genet. Cytogenet., Abstract only, 51(2):183-188 (1991).
Gerber et al.J. Biol. Chem., 273(46):30336-30343 (1998).
Gorman et al.Proc. Natl. Acad. Sci. USA, 79:6777-6781 (1982).
Green et al.J. Exp. Med., 188(3):483-495 (1998).
Green et al.Nature Genetics, 7:13-21 (1994).
Grosschedl et al.Cell, Abstract only, 41(3):885-897 (1985).
Hanes et al.Proc. Natl. Acad. Sci. USA, 94:4937-4942 (1997).
Hoogenboom et al.Immunol. Rev., Abstract only, 130:41-68 (1992).
Houghten et al.Biotechniques, 13(3):412-421 (1992).
HoughtenProc. Natl. Acad. Sci. USA, 82:5131-5135 (1985).
Ike et al.Nucl. Acid Res., 11(2):477-488 (1983).
Itakura et al.Annu. Rev. Biochem., Abstract only,53:323-356 (1984).
Katoh et al.J. Gastroenterol., 31(1):137-139 (1996).
Kessler et al.Science, 271:360-362 (1996).
Kostelny et al.J. Immunol., 148:1547-1553 (1992).
Kurahashi et al.Hum. Mol. Genet., 9(11):1665-1670 (2000).
LaPlanche et al.Nucl. Acids Res., 14(22):9081-9093 (1986).
LaRochelle et al.Nat. Cell Biol., 3:517-521 (2001).
Li et al.Cell Res., 9:11-25 (1999).
Liu et al.Proc. Natl. Acad. Sci. USA, 84:3439-3443 (1987).
Liu et al.J. Immunol., Abstract only,139(10):3521-3526 (1987).
Marasco,Gene Ther., Abstract only, 4(1): 11-15 (1997).
Masood et al.,Proc. Natl. Acad. Sci. USA, 94(3):979-984 (1997).
Mendez et al.Nat. Genet., 15:146-156 (1997).
Michaux et al.Genes, Chromosomes & Cancer, 29:40-47 (2000).
Narang,Tetrahedron, Abstract only, 39(1):3-22 (1983).
Needleman et al.J. Mol. Biol., 48:443-453 (1970).
Okayama et al.Mol. Cell. Biol., 3(2):280-289 (1983).
Parmley et al.Gene, Abstract only, 73(2):305-318 (1988).
Pearson et al.Proc. Natl. Acad. Sci. USA, 85:2444-2448 (1988).
Pinilla et al.Biotechniques, Abstract only, 13(6):901-905 (1992).
Pivnick et al.J. Med. Genet., Abstract only, 33(9):772-778 (1996).
Powell et al.PDA J. Pharm. Sci. Technol., Abstract only, 52(5):238-311 (1998).
Risau et al.,Annu. Rev. Cell Dev. Biol., 11:73-91 (1995).
Risau,FASEB J., 9(10):926-933 (1995).
Rizo et al.Annu. Rev. Biochem., Abstract only 61:387-418(1992).
Russell et al.Nucl. Acids Res., 21(5):1081-1085 (1993).
Scott,Trends Biochem. Sci., Abstract only, 17(7):241-245 (1992).
Shen et al.J. Surg. Oncol., Abstract only, 74(2):100-107 (2000).
Smith et al.Adv. Appl. Math., Abstract only, 2(4):482-489 (1981).
Songsivilai et al.Clin. Exp. Immunol., Abstract only, 79(3):315-321 (1990).
Speirs et al.Br. J. Cancer, 80(5/6):898-903(1999).
Stec et al.J. Am. Chem. Soc., Abstract only, 106:6077-6079 (1984).
Stein et al.Nucl. Acids Res., 16:3209-3221 (1988).
Tarkkanen et al.Genes, Chromosomes & Cancer, 25:323-331 (1999).
Thornton et al.Nature, 354:105-106 (1991).
Traunecker et al.Int. J. Cancer (Suppl.), Abstract only,7:51-52 (1992).
Uhlmann et al.Chem. Rev., Abstract only, 90(4):543 (1990).
Valerius et al.Blood, 90(11):4485-4492 (1997).
Veber et al.Trends in Neurosci., Abstract only, 8:392-396 (1985).
Vitetta et al.Immunol. Today, Abstract only,14(6):252-259 (1993).
Wang,Int. J. Pharm., 203(1-2):1-60 (2000).
Warren et al.J. Clin. Invest., 95:1789-1797 (1995).
Winter et al.Immunol. Today, Abstract only,14(6):243-246 (1993).
Wozney et al.Science, 242:1528-1534 (1988).
Wright et al.Crit. Rev. Immunol., Abstract only, 12(3-4):125-168 (1992).
Yoshikawa et al.Cancer, 56:1682-1687 (1985).
Yuan et al.Proc. Natl. Acad. Sci. USA, 93:14765-14770 (1996).
Zon et al.Anti-Cancer Drug Des., Abstract only,6(6):539-568 (1991).

Affiliated with

Also associated with

Rating

Antibodies directed to PDGFD and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies directed to PDGFD and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies directed to PDGFD and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3705213