Antibodies directed to G-protein coupled receptor HGPRBMY29sv1

Details Antibodies directed to G-protein coupled receptor HGPRBMY29sv1 Antibodies directed to G-protein coupled receptor HGPRBMY29sv1

2007-08-08

2009-12-22

Landsman, Robert (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C435S975000, C530S387300, C530S388100, C530S388150, C530S391100

Reexamination Certificate

active

07635758

ABSTRACT:
The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

REFERENCES:
patent: 5849902 (1998-12-01), Arrow et al.
patent: 7153678 (2006-12-01), Jackson et al.
patent: 7186564 (2007-03-01), Chen et al.
patent: 7358074 (2008-04-01), Jackson et al.
patent: WO00/15793 (2000-03-01), None
patent: WO00/40724 (2000-07-01), None
patent: WO 01/02563 (2001-01-01), None
patent: WO0100673 (2001-01-01), None
patent: WO0102563 (2001-01-01), None
patent: WO0125430 (2001-04-01), None
patent: WO0144281 (2001-06-01), None
patent: WO0168848 (2001-09-01), None
patent: WO01/98351 (2001-12-01), None
patent: WO0210387 (2002-02-01), None
patent: WO0222665 (2002-03-01), None
patent: WO0229050 (2002-04-01), None
patent: WO 02/061087 (2002-08-01), None
Stadel, et al., “Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery”, TIPS, vol. 18, pp. 430-437 (1997).
U.S. Appl. No. 60/306,803, filed Jul. 20, 2001, Feder et al.
NCBI Entrez Accession No. AA058394 (gi:1551409), Sep. 19, 1996.
NCBI Entrez Accession No. AAB36682 (gi:1685051), Gray, J.X. et al.; Sep. 30, 2002.
NCBI Entrez Accession No. AC026333 (gi:24431582), Muzny, D.M. et al., Mar. 15, 2003.
NCBI Entrez Accession No. AL161776 (gi:9931705), Sims, S., Jun. 13, 2001.
NCBI Entrez Accession No. AL551728 (gi:45856521), Feb. 15, 2001.
NCBI Entrez Accession No. AW357690 (gi:6861696), Feb. 3, 2000.
NCBI Entrez Accession No. AW657930 (gi:7423756), Apr. 5, 2000.
NCBI Entrez Accession No. AW998346 (gi:8258580), Jun. 5, 2000.
NCBI Entrez Accession No. BAA34478 (gi:3882237), Nagase, T. et al., Jun. 16, 1999.
NCBI Entrez Accession No. BAA82518 (gi:5525078), Abe, J. et al., Jul. 22, 1999.
NCBI Entrez Accession No. BAB31767 (gi:12859760), Carninci, P. et al., Apr. 30, 2004.
NCBI Entrez Accession No. BE243318 (gi:9095053), Jul. 13, 2000.
NCBI Entrez Accession No. BF160755 (gi:11040862), Oct. 27, 2000.
NCBI Entrez Accession No. BG757374 (gi:14068027), May 14, 2001.
NCBI Entrez Accession No. B1518500 (gi:15343292), Aug. 28, 2001.
NCBI Entrez Accession No. B1540125 (gi:15381237), Aug. 30, 2001.
NCBI Entrez Accession No. BJ062663 (gi:17424297), Dec. 7, 2001.
NCBI Entrez Accession No. BJ062997 (gi:17470757), Dec. 10, 2001.
NCBI Entrez Accession No. BM052876 (gi:16808668), Nov. 8, 2001.
NCBI Entrez Accession No. BM147960 (gi:17168247), Nov. 30, 2001.
NCBI Entrez Accession No. BM148818 (gi:17169886), Nov. 30, 2001.
NCBI Entrez Accession No. BM193863 (gi:17652455), Dec. 13, 2001.
NCBI Entrez Accession No. CAB37294 (gi:4456467), Zendman, A.J. et al., Aug. 17, 1999.
NCBI Entrez Accession No. CAB42901 (gi:4826465), Mashreghi-Mohammadi, M., Nov. 23, 1999.
NCBI Entrez Accession No. NP—005747 (gi:5031733), Obermann, H. et al., Sep. 3, 2004.
NCBI Entrez Accession No. NP—061370 (gi:9256531), Kawai, J. et al., Apr. 7, 2003.
AbdAlla, S. et al., “AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration”, Nature, vol. 407, pp. 94-98 (2000).
Aggarwal, B.B., “Apoptosis and Nuclear Factor-κB: A Tale of Association and Dissociation”, Biochemical Pharmacology, vol. 60, pp. 1033-1039 (2000).
Akbar, G.K.M. et al., “Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells”, The Journal of Biological Chemistry, vol. 271, No. 31, pp. 18363-18367 (1996).
Altschul, S.F. et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”, Nucleic Acids Research, vol. 25, No. 17, pp. 3389-3402 (1997).
Applebury, M.L. et al., “Molecular Biology of the Visual Pigments”, Vision Res., vol. 26, No. 12, pp. 1881-1895 (1986).
Attwood, T.K. et al., “Multiple sequence alignment of protein families showing low sequence homology: a methodological approach using database pattern-matching discriminators for G-protein linked receptors”, Gene, vol. 98, pp. 153-159 (1991).
Aust, G. et al., “CD97: A Dedifferentiation Marker in Human Thyroid Carcinomas”, Cancer Research, vol. 57, pp. 1798-1806 (1997).
Baldwin, A.S., “Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB”, The Journal of Clinical Investigation, vol. 107, No. 3, pp. 241-246 (2001).
Baldwin, J.M., “Structure and function of receptors coupled to G proteins”, Current Opinion in Cell Biology, vol. 6, pp. 180-190 (1994).
Baldwin, Jr., A.S., “The transcription factor NF-κB and human disease”, The Journal of Clinical Investigation, vol. 107, No. 1, pp. 3-6 (2001).
Barnard, E.A. et al., “G protein-coupled receptors for ATP and other nucleotides: a new receptor family”, Trends in Pharmacological Sciences, vol. 15, pp. 67-70 (1994).
Basu, S. et al., “The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage”, Biochemical and Biophysical Research Communications, vol. 247, No. 1 pp. 79-83 (1998).
Bateman, A. et al., “The Pfam Protein Families Database”, Nucleic Acids Research, vol. 28, No. 1, pp. 263-266 (2000).
Baud, V. et al., “EMR1, an Unusual Member in the Family of Hormone Receptors with Seven Transmembrane Segments”, Genomics, vol. 26, pp. 334-344 (1995).
Baud, V. et al., “Signal transduction by tumor necrosis factor and its relatives”, Trends in Cell Biology, vol. 11, No. 9, pp. 372-377 (2001).
Bause, E., “Structural requirements ofN-glycosylation of proteins: Studies with proline peptides as conformational probes”, Biochem. J., vol. 209, pp. 331-336 (1983).
Bolander, F.F., Molecular Endocrinology, Second Edition, Academic Press, Inc., publ., pp. 162-176 (1994).
Bradbury, A.F. et al., “Biosynthesis of the C-Terminal Amide in Peptide Hormones”, Bioscience Reports, vol. 7, No. 12, pp. 907-916 (1987).
Branchek, T., “More serotonin receptors?”, Current Biology, vol. 3, No. 5, pp. 315-317 (1993).
Chapot-Chartier, M.-P. et al., “Cloning and Sequencing ofpepC, a Cysteine Aminopeptidase Gene fromLactococcus lactissubsp.cremorisAM2”, Applied and Environmental Microbiology, vol. 59, No. 1, pp. 330-333 (1993).
Cornfield, L.J. et al., “[3H]2-Phenylaminoadenosine ([3H]CV 1808) Labels a Novel Adenosine Receptor in Rat Brain”, The Journal of Pharmacology and Experimental Therapeutics, vol. 263, No. 2, pp. 552-561 (1992).
Coughlin, S.R., “Expanding horizons for receptors coupled to G proteins: diversity and disease”, Current Opinion in Cell Biology, vol. 6, pp. 191-197 (1994).
Desdouets, C. et al., “p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer”, Pathol. Biol., vol. 48, pp. 203-210 (2000).
Draetta, G.F., “Mammalian G1cyclins”, Current Opinion in Cell Biology, vol. 6, pp. 842-846 (1994).
Dufour, E., “Sequence homologies, hydrophobic profiles and secondary structures of cathepsins B, H and L: comparison with papain and actinidin”, Biochimie, vol. 70, pp. 1335-1342 (1988).
Eichler, W. et al., “Expression characteristics of the human CD97 antigen”, Tissue Antigens, vol. 50, pp. 42

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