Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-07-05
2005-07-05
Chin, Christopher L. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S070210, C435S452000, C435S332000, C435S334000, C436S501000, C436S518000, C436S548000, C530S388200, C530S388220
Reexamination Certificate
active
06913894
ABSTRACT:
Monoclonal antibodies which bind specifically to the extracellular domain of the SIRP cell surface glycoproteins, and which, in some cases, block the interaction of SIRP with the surface molecule CD47, are described.
REFERENCES:
patent: WO 97/48723 (1997-12-01), None
patent: WO 99/40940 (1999-08-01), None
patent: WO 00/66159 (2000-11-01), None
Adams, S., et al. ( 1998) Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells. J. Immunol. 161:1853-1859.
Dietrich, J., et al. (2000) Cutting Edge: Signal-Regulatory Protein β1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells. J. Immunol. 164:9-12.
Kharitonenkov, A., et al. (1997) A Family of Proteins That Inhibit Signalling Through Tyrosine Kinase Receptors. Nature 386(13):181-186.
Seiffert, M., et al. (1998) Expression and Function of SIRPα1 and its Extracellular Ligand on Hematopoietic Cells. (Abstract) Blood 92(10): Suppl. 1, Part 1-2: 160B.
Seiffert, M., et al. (1999) Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD47. Blood 94(11):3633-3643.
Seiffert, M., et al. (1999) Molecular Characterization of SIRPα-CD47 Interactions on Hematopoietic Cells. (Abstract) Blood 94(10): Suppl 1, Part 1:47A.
Seiffert, M., et al. (2000) Expression and Function of Signal-Regulatory Proteins (SIRPs): SIRPα but not SIRPβ is Expressed on Hematopoietic Stem Cells and Interacts with CD47. Tissue Antigens 55(Suppl 1):70-71.
Bühring Hans-Jörg
Cant Charles
Chen Zhengjun
Ullrich Axel
Chin Christopher L.
Eberhard-Karls-Universitat Tubingen Universitatsklinikum
Grun James L.
Knobbe Martens Olson & Bear LLP
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