Antibodies directed against prothrombin fragment F1+2, the...

Details Antibodies directed against prothrombin fragment F1+2, the... Antibodies directed against prothrombin fragment F1+2, the...

2009-11-16

2011-11-22

Szperka, Michael (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

C435S007100, C435S007930, C424S139100, C424S141100, C424S145100, C424S184100, C530S387900, C530S388100, C530S388250

Reexamination Certificate

active

08063180

ABSTRACT:
The invention relates to antibodies directed against F1+2, to the preparation and use thereof, especially in therapy and diagnosis. The antibodies bind to an epitope on the N-terminal half of the F2fragment of prothrombin.

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Janeway et al., Immunobiology, 3rdedition, 1997, Garland Publishing, pp. 2:6-2:8.
Church et al., Modulation of Human Prothrombin Activation on Phospholipid Vesicles and Platelets Using Monoclonal Antibodies to Prothrombin Fragment 2, J. Biol. Chem. 266:8384-8391 (1991).
Kim et al., A Peptide Derived from Human Prothrombin Fragment 2 Inhibits Prothrombinase and Angiogenesis, Thrombosis Research 106:81-87 (2002).
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Bezeaud et al., Quantitation of Prothrombin Activation Products in Human Urine, British Journal of Haematology 58:597-606 (1984).

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