Antibodies directed against elk ligand

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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53038823, 4241391, C07K 1624

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active

057288135

ABSTRACT:
Antibodies to elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.

REFERENCES:
patent: 5134121 (1992-07-01), Mobley et al.
patent: 5512457 (1996-04-01), Lyman et al.
patent: 5516658 (1996-05-01), Beckmann et al.
patent: 5599669 (1997-02-01), Dixit
patent: 5627267 (1997-05-01), Lyman et al.
Cerretti et al., "Isolation of cDNAs that Encode Ligands to the Receptor Tyrosine Kinases Hek and Elk: Emergence of a Family of Proteins that are Ligands for the Eph Related Kinases (LERKS)", Abstract for American Assoc. for Cancer Research conference on Growth Factors, Development, and Cancer, held in Interlaken, Switzerland, Mar. 5-11, 1994.
Lyman et al., "Identification of a Ligand for the Elk Tyrosine Kinase Receptor", Lymphokine and Cytokine Research, vol. 12, No. 5, Abstract No. 92, Oct., 1993.
Beckmann et al., "Molecular Characterization of a Family of Ligands for Eph-Related Tyrosine Kinases", Abstract for Keystone Symposium on Inflammation, Growth Regulatory Molecules, and Atherosclerosis, Keystone, CO, Jan. 16-23, 1994.
M. Flint Beal, "Role of excitotoxicity in human neurological disease", Current Opinion in Neurobiology, 2:657-662, 1992.
Dennis W. Choi, "Excitotoxic Cell Death", J. Neurobiology, 23:1261-1276, 1992.
Massieu et al., "A Comparative Analysis of the Neuroprotective Properties of Competitive and Uncompetitive N-Methyl-D-Aspartate Receptor Antagonists In Vivo: Implications for the Process of Excitotoxic Degeneration and its Therapy", Neuroscience, 55:883-892, 1993.
Albin and Greenamyre, "Alternative excitotoxic hypotheses", Neurology 42:733-738, 1992.
Letwin et al., "Novel protein-tyrosine kinase cDNAs related to fpslfes and eph cloned using anti-phosphoryrosine antibody", Oncogene 3:621-627, 1988.
Lhotak et al., "Characterization of Elk, a Brain-Specific Receptor Tyrosine Kinase", Mol. Cell. Biol. 11:2496-2502, 1991.
Boyd et al., "Isolation and Characterization of a Novel Receptor-type Protein Tyrosine Kinase (hek) from a Human Pre-B Cell Line", J. Biol. Chem. 267:3262-3267, 1992.
Wicks et al., "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinse expressed by human lymphoid tumor cell line", Proc. Natl. Acad. Sci. USA 89:1611-1615, 1992.
Saijadi et al., "Identification of a New eph-Related Receptor Tyrosine Kinase Gene From Mouse and Chicken That Is Developmentally Regulated and Encodes at Least Two Forms of the Receptor", New Biol. 3:769-788, 1991.
Chan and Watt, "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases", Oncogene 6:1057-1061, 1991.
Lindberg et al., "cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases", Mol. Cell. Biol. 10:6316-6324, 1990.
Pasquale, "Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family", Cell Regulation 2:523-534, 1991.
Hirai et al., "A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene", Science 238:1717-1720, 1987.
Holzman et al., "A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein", Mol. Cell. Biol. 10:5830-5838, 1990.
Ashkenazi et al., "Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin", Proc. Natl. Acad. Sci. USA 88:10535-10539, 1991.
Byrn et al., "Biological properties of a CD4 immunoadhesin", Nature 344:667-670, 1990.
Beckmann et al., "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors", EMBO J. 13:3757-3762, 1994.
Bohme et al., "Cell-Cell Adhesion Mediated by Binding of Membrane-anchored Ligand LERK-2 to the EPH-related Receptor Human Embryonal Kinase 2 Promotes Tyrosine Kinase Activity", J. Biol. Chem. 271:24747-24752, 1996.

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