Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1999-11-04
2000-11-07
Park, Hankyel
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303913, 5303917, 4241601, C07K 1600, A61K 3942
Patent
active
061438766
ABSTRACT:
Binding of two members of a binding couple reveals epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher affinity than their binding affinity to either of the two members themselves when not bound to one another.
REFERENCES:
The Faseb Journal, vol. 7, No. 12, issued Sep. 1993, Gershoni et al., "HIV binding to its receptor creates specific epitopes for the CD4/gp 120 complex," pp. 1185-1187.
Journal Of Experimental Medicine, vol. 172, issued Oct. 1990, Caleda et al., "Antibody raised against soluble CD4-rgp 120 complex recognizes the CD4 moiety and blocks membrane fusion without inhibiting CD4-gp 120 binding," pp. 1143-1150.
Parasitology, vol. 88, issued 1984, Ortega et al., The occurrence of antibodies to hidden and exposed determinants of surface antigens of Trichinella spiralis, pp. 359-369.
Abstract 586686, Journal of Laboratory Clinical Medicine, vol. 86, No. 5, issued 1975, Javid et al., "The modification of hemoglobin antihemiglobin reaction by haptoglobin," pp. 777-784.
Abstract 6538081, British Journal of Haematology, vol. 68, No. 3, issued 1988, Nordfang et al., "Radioimmunoassay afor quantitative measurement of Factor VIII-heavy chain," pp. 307-312.
Abstract 207470, Scandinavian Journal of Immunology, vol. 3, No. 2, issued 1974, Lind et al., Immunochemical study of the interaction between staphylococcal protein A, rabbit antistaphyloccoccal sera, and selected sera from nonimmunized animals, pp. 147-156.
Abstract 407661, Scandinavian Journal of Immunology, vol. 3, No. 6, issued 1974, Lind., I., "The formation of antibodies against hidden determinants of autologous IgG during immunization of rabbits with Staphylococcus aureus," pp. 689-696.
Abstract 359023, International Journal of Parasitology, vol. 4, No. 6, issued 1974, Boreham et al., "Autoimmunity in trypansome infections II. Anti fibrin/fibrinogen (anti-F) autoantibody in Trypanosoma (Trypanozoon) brucei infections of the rabbit," pp. 601-607.
Abstract 9626985, Journal of Immunology, vol. 149, No. 6, issued 1992, Callahan et al., "Analysis of HIV-induced autoantibodies to cryptic epitopes on human CD4," pp. 2194-2202.
Park Hankyel
Ramot University Authority for Applied Research and Industrial
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