Antibodies catalyzing deamidation of proteins

Details Antibodies catalyzing deamidation of proteins Antibodies catalyzing deamidation of proteins

1992-04-08

1995-08-08

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4351885, 435229, 5303889, 5303898, C12N 900, C12N 982, C12P 1314

Patent

active

054398126

ABSTRACT:
A hapten is described which may be used to elicit antibodies that catalyze the deamidation of asparginyl-glycyl dipeptides to form two products, the isoaspartyl-glycyl dipeptide and the aspartyl-glycyl dipeptide. A general synthetic scheme is also presented which shows how to modify the hapten to provide specificity for a particular protein in the antibodies that are elicited by the (modified) hapten. Antibodies which catalyze the the deamidation reaction are also described.

REFERENCES:
patent: 5079152 (1992-01-01), Benkovic et al.
R. A. Lerner, et al., Science, vol. 252, pp. 659-667 (1991).
G. Kohler, et al., Nature, vol. 256, pp. 495-497 (1975).
A. B. Robinson, et al., Curr. Top. Cell. Regul., vol. 8, pp. 247-295 (1974).
F. Fonseca-Wollheim, Clin. Chem., vol. 36/8, pp. 1483-1487, (1990).
J. Kyte, et al., J. Mol. Biol., vol. 157, pp. 105-132, (1982).
L. Sastry, et al., Proc. Nat'l. Acad. Sci. USA, vol. 86, pp. 5728-5732 (1989).
W. D. Huse, et al., Science, vol. 246, pp. 1275-1281 (1989).
M. Better, et al., Science, vol. 240, pp. 1041-1043 (1988).
A. S. Kang, et al., Proc. Nat'l. Acad. Sci. USA, vol. 88, pp. 4363-4366 (1991).
Liottz, L. J., et al., (1993) J. Am. Chem. Soc. 115, 350-351.
Gibbs, R. A., et al. (1992) Science 258, 803-805.

Affiliated with

Also associated with

Rating

Antibodies catalyzing deamidation of proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies catalyzing deamidation of proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies catalyzing deamidation of proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-970609