Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-08-29
2006-08-29
Winkler, Ulrike (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S139100, C424S141100
Reexamination Certificate
active
07098317
ABSTRACT:
The present invention pertains to novel antibodies directed to the C-terminal part of the PrPScisoform of prions. In particular, the present invention pertains to the use of such antibodies in the diagnosis of bovine spongiform encephalopathy (BSE) and the new variant form of Creutzfeld Jacobs Disease (vCJD). In addition, the present invention relates to the peptide recognized by the antibodies and its use in the immunization and/or treatment of BSE, CJD, vCJD and other TSE related diseases.
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Korth et al. Prion (PrPSc)-specific epitope defined by monoclonal antibody. Nature (1997) vol. 390, pp. 74-78.
Kocisko et al., “Partial Unfolding and Refolding of Scrapie-Associated Prion Protein: Evidence for a Critical 16-kDa C-Terminal Domain,”Biochemistry35:13434-13442 (1996).
Muramoto et al., “Recombinant Scrapie-Like Prion Protein of 106 Amino Acids is Soluble,”Proc. Natl. Acad. Sci. USA, 93:15457-15462 (1996).
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{hacek over (C)}urin-{hacek over (S)}erbec, “Site-Directed Monoclonal Antibody Specifically Recognizes PrPSc,”Vox Sanguinis—26thCongress of the International Society of Blood Transfusions, Viena, Austria 78(1):57 (2000) (abstract).
Blood Transfusion Center of Slovenia
Nixon & Peabody LLP
Winkler Ulrike
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