Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-05-09
2006-05-09
Nolan, Patrick J. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S387900, C530S388200, C530S389600
Reexamination Certificate
active
07041801
ABSTRACT:
The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particularly, the invention related to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a functional gene product, and methods of using the gene and gene product. Since del-1 is expressed in endothelial cells and certain cancer cells, it may be useful as an endothelial cell and tumor marker. In addition, anti-Del-1 antibodies for immunological assessment of Del-1 protein expression as well as for inhibiting or stimulating Del-1 function are provided.
REFERENCES:
patent: 4215051 (1980-07-01), Schroeder et al.
patent: 4868112 (1989-09-01), Toole, Jr. et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5096825 (1992-03-01), Barr et al.
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5505955 (1996-04-01), Peterson et al.
patent: 5506107 (1996-04-01), Cunningham et al.
patent: 5508199 (1996-04-01), Gonzalez et al.
patent: 6168946 (2001-01-01), Houghton et al.
patent: 94/11508 (1994-05-01), None
patent: 96/40769 (1996-12-01), None
Allen et al., “Transgenes as probes for active chromosomal domains in mouse development,”Nature333:852-855 (1988).
Anderson, 1990, “Adhesion molecules and animal development,” Experentia 46:2-13.
Aruffo et al., “CD44 is the principal cell surface receptor for hyaluronate,”Cell61:1303 (1990).
Ausubel et al.(editor),Current Protocols in Molecular Biology, John Wiley & Sons (1994) (Table of Contents for vols. 1 & 2).
Bevilacqua et al., “Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins,”Science243:1160-1165 (1989).
Bevilacqua et al., “Selectins,”J. Clin. Invest.91:379-387 (1993).
Bhat et al., “Functional cloning of mouse chromosomal loci specifically active in embryonal carcinoma stem cells,”Mol. Cell. Biol.8:3251-3259 (1988).
Bisgrove et al., “The spEGF III gene encodes a member of the fibropellins: EGF repeat-containing proteins that form the apical lamina of the sea urchin embryo,”Develop. Biol.157:526-538 (1993).
Bitter et al., “Expression and secretion vectors for yeast,”Methods in Enzymology153:516-544 (1987).
Bitter, Heterologous Gene Expression in Yeast,Methods in Enzymology152:673-684 (1987).
Breier et al., “Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation,”Development114:521-532 (1992).
Brisson et al., “Expression of a bacterial gene in plants by using a viral vector,”Nature310:511-514 (1984).
Broglie et al., “Light-regulated expression of a pea riboluse-1,5-biphosphate carboxylase small subunit gene in transformed plant cells,”Science224:838-843 (1984).
Brooks et al., 1994, “Integrin αvβ3antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels,” Cell 79:1157-1164.
Broudy et al., “Interluekin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor,”J. Immunol.139:464-468 (1987).
Caruthers et al., “New chemical methods for synthesizing polynucleotides,”Nuc. Acids Res. Symp. Ser.7:215-233 (1980).
Chow et al., “Synthesis of oligodeoxyribonucleotides on silica gel support,”Nuc. Acids Res.9(12):2807-2817 (1981).
Coffin et al., “Endothelial cell origin and migration in embryonic heart and cranial blood vessel development,”Anat. Rec.231:383-395 (1991).
Colberre-Garapin et al., “A new dominant hybrid selective maker for higher eukaryotic cells,”J. Mol. Biol.150:1-14 (1981).
Cole et al., “The EBV-Hybridoma technique and its application to human lung cancer,”Monoclonal Antibodies and Cancer Therapypp. 77-96 (1985).
Coruzzi et al., “Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of riboluse-1, 5-bisphosphate carboxylase,”EMBO J.3:1671-1680 (1984).
Cote et al., “Generation of human monoclonal antibodies reactive with cellular antigens,”Proc. Natl. Acad. Sci.80:2026-2030 (1983).
Cotran et al., “Cytokine-endothelial interactions in inflammation, immunity, and vascular injury,”J. Am. Soc. Nephrol.1:225-235 (1990).
Couso et al., 1994, “Notch is required for wingless signaling in the epidermis of drosophila,” Cell 79:259-272.
Crea et al., “Synthesis of oligonucleotides on cellulose by a phosphotriester method,”Nuc. Acids Res.9(10):2331-2348 (1980).
Creighton,Proteins Structures and Molecular Principles,W.H. Freeman and Co., N.Y. pp. 34-60 (1983).
Crowley et al., 1985, Phenocopy of discoidin I-minus mutants by antisense transformation in dictyostelium, Cell 43:633-641.
Current Protocols in Molecular Biology, vol. 2, Ed. Ausubel et al., Greene Publish. Associ. & Wiley Interscience, Ch. 13 (1988).
Del Amo et al., “Expression pattern of Motch, a mouse homolog of drosphila notch, suggests an important role in early postimplantation mouse development,”Development115:737-744 (1992).
Doolittle, “The genealogy of some recently evolved vertebrate proteins,”TIBSpp. 233-237 (1985).
Dumont et al., “tek- a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors,”Oncogene7:1471-1480 (1992).
Dumont et al., “The endothelial-specific receptor tyrosine kinase, TEK, is a member of a new subfamily of receptors,” Oncogene 8(5):1293-1301 (1993).
Durkin et al., “Amino acid sequence an domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor,”J. Cell. Biol.107:2749-2756 (1988).
Ekblom et al., “Role of mesenchymal nidogen for epithelial morphogenesis in vitro,”Development120:2003-2014 (1994).
Ellisen et al., “TAN-1, the human homolog of the drosphila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms,”Cell66:649-661 (1991).
Engel, “EGF-like domains in extracellular matrix proteins: Localized signals for growth and differentiation,”FEBS Lett.251:1-7 (1989).
Familari et al., GenBank Accession No. L14608 (accessed Dec. 18, 1997) Jul. 14, 1993.
Fidler et al., “The implications of angiogenesis for the biology and therapy of cancer metastasis,”Cell79:185-188 (1994).
Folkman and Shing, “Angiogenesis,”J. Biol. Chem.267:10931-10934 (1992).
Folkman et al., “Angiogenic factors,”Science235:442-447 (1987).
Fong et al., “Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer,”Cancer Res.55:220-223 (1995).
Fortini et al., 1994, “The suppressor of hairless protein participates in notch receptor signaling,” Cell 79:273-282.
Francke, “Digitized and differentially shaded human chromosome ideograms for genomic applications,”Cytogenet. Cell Genet.65:206-219 (1994).
Frazier, “Thrombospondin: A modular adhesive glycoprotein of platelets and nucleated cells,”J. Cell. Biol.105:625 (1987).
Fukuzawa et al., 1988, “Monoclonia antibodies against discoidin I and discoidin II of the cellular slime mold Dictyosteium discoideum,” J. Biochem 103:884-888.
Gimbrone et al., “Endothelial interleukin-8: A novel inhibitor of leukocyte-endothelial interactions,”Science246:1601-1603 (1989).
Granger et al., “Molecular and cellular basis of myocardial angiogenesis,”Cell and Mol. Biol. Res.40:81-85 (1994).
Grierson et al.,Plant Molecular Biology2ndEd. Blackie, London Ch. 7-9 (1988).
Gunning et al., “A Human β -actin Expression Vector System Directs High-level Accumulation of Antisense Transcripts,”Proc. Natl. Acad. Sci. USA84:4831-4835 (1987).
Gurley
Hogan Brigid
Quertermous Thomas
Snodgrass H. Ralph
Zupancic Thomas Joel
Nolan Patrick J.
Valentis, Inc.
Vanderbilt University
LandOfFree
Antibodies binding to polypeptides encoded by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies binding to polypeptides encoded by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies binding to polypeptides encoded by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3599853