Antibodies binding to human TSLP Polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S350000, C530S387100, C530S388100, C530S387300, C424S130100, C424S134100, C424S139100, C424S141100, C424S145100, C514S002600

Reexamination Certificate

active

10376406

ABSTRACT:
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.

REFERENCES:
patent: 5011912 (1991-04-01), Hopp et al.
patent: 2003/0099947 (2003-05-01), Bazan et al.
patent: WO 00/17362 (2000-03-01), None
patent: WO 00/39149 (2000-06-01), None
GenBank Accession No. AA889581, “EST; h. sapiens cDNA clone IMAGE: 1407260,” Apr. 6, 1998.
Friend, S.L., and Far, A., “Initial characterization of Thymic Stromal Derived Lymphopoietn (TSLP),”FASEB J. 8: A506, 1994 (Abstract).
Lai, L. et al., Identification of an IL-7 associated pre-pro-B cell growth-stimulating factor (PPBSF) II. PPBSF is a covalently linked heterodimer of IL-7 and a Mt30,000 Co-factor1,J. Immunol. 160:2280-2286, Mar. 1, 1998.
Ray, R.J. et al., “Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro,”Eur. J. Immunol. 26: Jan. 10-16, 1996.
Friend, S.L. et al., “A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells,”Exp. Hematology 22(3): 321-328, Mar. 1994.
Candéias, S. et al., “Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice,”Immunol. Lett., 57:9-14, 1997.

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