Antibodies binding portions, and probes recognizing an antigen o

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

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435 721, 435 723, 4241381, 4241411, 4241521, 4241551, 5303875, 5303877, 5303882, 5303888, 5303891, 5303897, 5303911, 5303913, 5303917, C07K 1628, A61K 39395, C12N 512, G01N 3353

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active

057732922

ABSTRACT:
The present invention is directed to the use of antibodies or binding portions thereof or probes which recognize an antigen of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof. These antibodies or binding portions thereof or probes can be labeled and used for detection of such cells. They also can be used alone or bound to a substance effective to ablate or kill such cells as a therapy for prostate cancer. Also disclosed is a hybridoma cell line which produces a monoclonal antibody recognizing antigens of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof.

REFERENCES:
patent: Re33405 (1990-10-01), Chu et al.
patent: 4446122 (1984-05-01), Chu et al.
patent: 4675287 (1987-06-01), Reisfeld et al.
patent: 4840915 (1989-06-01), Bogoch
patent: 4863851 (1989-09-01), McEwan et al.
patent: 4902615 (1990-02-01), Freeman et al.
patent: 4970299 (1990-11-01), Bazinet et al.
patent: 5055404 (1991-10-01), Ueda et al.
patent: 5118611 (1992-06-01), Smith et al.
patent: 5130129 (1992-07-01), Pardridge
patent: 5135737 (1992-08-01), Keana
patent: 5242824 (1993-09-01), Hellstrom et al.
patent: 5250297 (1993-10-01), Grauer et al.
patent: 5367060 (1994-11-01), Vandlen et al.
Webb, Cancer Immunol Immunother 17:7-17, 1984.
Raynor JNCI 73:617-623, 1984.
Raynor The Prostate 9:21-31, 1986.
Ware Cancer Research 42:1215-1222, 1982.
Carroll Clin. Immunol Immunopathol 33:268-281, 1984.
Lopes Cancer Research 50:6423-6429 1990.
Starling Cancer Research 46:367-374 1986.
Theyer J. Urology 150: 1544-1547, 1993.
Leroy, Cancer 64: 1-5 1989.
Seaver, Gen. Eng. News V14, pp. 10-21, Aug. 1994.
Colher, Methods in Enzymology 121: 802-816 1986.
Bayer, Clinical Laboratory Methods, 9th ed., St. Louis: C. V. Mosby Company, Chapter 35, "Clinical Serology," pp. 1025-1063 (1982).
Raynor et al., "Localization of a Normal Prostatic Secretory Product Using the Monoclonal Antibody, KR-P8," Federation Proceedings, 44:793 (1985).
Raynor et al., "Localization of a Normal Prostatic Secretory Product Using the Monoclonal Antibody, KR-P8," Journal of Urology, 134:384-387 (1985).
Guinan et al., "An Evaluation of Prostate Specific Antigen in Prostatic Cancer," Journal of Urology, 137:686-689 (1987).
Guinan et al., "Methods of Early Diagnosis in Genitourinary Cancer," Cancer, 60:668-676 (1987).
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor, New York:Cold Spring Harbor Laboratory, Chapter 14, "Immunoassays," pp. 553-612 (1988).
Vitetta et al., "Redesigning Nature's Poisons top Create Anti-Tumor Reagents," Science, 238:1098-1104 (1987).
Dillman, "Monoclonal Antibodies for Treating Cancer," Annals of Internal Medicine, 111:592-602 (1989).
Waldmann, "Monoclonal Antibodies in Diagnosis and Therapy," Science, 252:1657-1662 (1991).

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