Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2001-03-01
2008-10-21
Saunders, David A (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007400, C435S007900, C435S007920, C435S069600, C435S070210, C436S518000, C436S530000, C436S547000, C436S548000, C530S387900, C530S413000
Reexamination Certificate
active
07439025
ABSTRACT:
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while not reacting with glutamic (Glu) residues in corresponding proteins and/or peptides. Methods for the preparation and identification of said antibodies as well as methods for detection of Gla in biological fluids, tissue extracts, tissue specimens, in which methods said antibodies are used, are also described. There is also described the use of said antibodies for immunopurification of Gla-containing proteins or peptides by, for instance, immunoprecipitation or immunoaffinity chromatography.
REFERENCES:
patent: 5229490 (1993-07-01), Tam
patent: 6379975 (2002-04-01), Linse et al.
patent: 6624295 (2003-09-01), Adams et al.
patent: 2003/0138844 (2003-07-01), Stenflo et al.
patent: 4008546 (1990-09-01), None
patent: 0 645 630 (1995-03-01), None
patent: WO 94/08615 (1994-03-01), None
patent: WO 99/09058 (1999-02-01), None
Roitt, Essential immunology, 5th ed., Blackwell Scientific Publications, 1984, pp. 6-8.
Brown, et. al., 2000, “Identification and Purification of Vitamin-K dependent Proteins and Peptides with Monoclonal Antibodies Specific for γ-Carboxyglutamyl (Gla) Residues.”J. of Biol Chem.275(26):19795-19802.
Eguchi et al., 1999, “Sandwich immunoassay specific for he N-terminal sequence of osteocalcin.”J. Immunol. Methods.184:231-240.
Koyama et al., 1991, “A one step sandwich enzyme immunoassay for γ-carboxylated osteocalcin using monoclonal antibodies.”J. of Immunol. Methods.139:17-23.
Tam, 1988, “Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.”Proc. Natl. Acad. Sci.85(15):5409-5413.
TaKaRa Bio, Inc., TaKaRa Biotechnology Catalog on-line for “Gla-type Osteocalcin (Gla-OC)/Undercarboxylated Osteocalcin (Glu-OC) EIA kit (Precoated)” (visited Feb. 5, 2007) http://bio.takara.co.jp/bio—en/Catalog—d.asp?C—ID=C0463.
Brown Mark Alan
Stenberg Loisa Mary
Stenflo Johan
Jones Day
Protease AB
Saunders David A
LandOfFree
Antibodies binding a gamma carboxyglutamic acid displaying... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies binding a gamma carboxyglutamic acid displaying..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies binding a gamma carboxyglutamic acid displaying... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4000959