Antibodies and utilization thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C435S007100, C435S007920, C435S007930, C435S007940, C435S007950, C435S070100, C435S070200, C435S070210, C436S518000, C436S514000, C436S547000, C436S548000, C530S380000, C530S388100, C530S388200

Reexamination Certificate

active

07067268

ABSTRACT:
The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.The immunoassay method using the monoclonal antibodies of the invention by the sandwich technique (in particular the sandwich technique using the monoclonal antibody and an antibody recognizing an intermediate portion of the 19P2 ligand) can assay the 19P2 ligand or a derivative thereof specifically and with high sensitivity. This assay method can be used in elucidating the physiological functions of the 19P2 ligand or a derivative thereof.

REFERENCES:
patent: 887417 (1998-12-01), None
patent: WO 97/24436 (1997-07-01), None
patent: WO 98/49295 (1998-11-01), None
Stongin., 1993. “Sensitivity, Specificity, and Predictive Value of Diagnostic Tests: Definitions and Clinical Applications”, in Laboratory Diagnosis of Viral Infections, Lennette, E., ed. Marcel Dekker, Inc. New York, pp. 211-219.

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