Antibodies, and methods for their use

Details Antibodies, and methods for their use Antibodies, and methods for their use

1995-06-02

1999-01-05

Saunders, David

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241781, 5303873, 5303911, A61K 39395, C07K 1600

Patent

active

058558861

ABSTRACT:
This invention relates to antibodies and is particularly, though not exclusively, concerned with diagnostic and therapeutic methods' using monoclonal, bi-or tri-specific antibodies. The invention also provides a method in which binding of a first antigen to a first antibody antigen binding site cause release of a second antigen from an adjacent second antibody antigen binding site.

REFERENCES:
patent: 4446233 (1984-05-01), Auditure-Hargreaves et al.
patent: 4578360 (1986-03-01), Smith
patent: 4686181 (1987-08-01), Dona
patent: 5273743 (1993-12-01), Ahlem
patent: 5501854 (1996-03-01), Raso
Suresh et al., "Advantages of Bispecific Hybridomas in One-Step Immunocytochemistry and Immunoassays", Proc. Natl. Acad. Sci. USA, 83:7989-7993 (1986).
De Lau et al., "Production of Hybrid Hybridomas based on HAT.sup.s -Neomycin.sup.r Double Mutants", J. Immunological Methods 117:1-8 (1989).

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