Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-10-31
2011-10-18
Sang, Hong (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S178100
Reexamination Certificate
active
08039593
ABSTRACT:
The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells.
REFERENCES:
patent: WO 2006/071441 (2006-07-01), None
Chen et al., Current Drug Delivery, 2004, 1(4): 361-376.
Kuan et al.: “GPNMB: A New Target for Human High-Grade Gliomas (HGL) Immunotherapy” Neuro-Oncology, [Online] vol. 7, No. 3, Jul. 2005, pp. 369-369, XP002420602.
Kam Fai Tse et al.: “CR011, a Potent Fully Human Monoclonal Antibody-Auristatin E Conjugated Prodrug Targeting Melanoma” Proceedings of the Annual Meeting of the American Association for Cancer Research, New York, NY, US, Apr. 16, 2005, XP002403962.
Tse Kam Fai et al.: “CR011, a Fully Human Monoclonal Antibody-Auristatin E Conjugate, for the Treatment of Melanoma” Clinical Cancer Research , The American Association for Cancer Research, US, vol. 12, No. 4, Feb. 15, 2006, pp. 1373-1382, XP002403963.
Kuan Chien-Tsun et al. : “Glycoprotein Nonmetastatic Melanoma Protein B, a Potential Molecular Therapeutic Target in Patients with Gliblastoma Mutliforme.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol. 12, No. 7, Pt. 1, Apr. 1, 2006, pp. 1970-1982, XP002420603.
Kuan C-T et al.: “Monoclonal Antibodies Recognizing Human GPNMBWT/GPNBSV React With Human High-Grade Gliomas (HGL)” Proceedings of the Annual Meeting of the American Association for Cancer Research, New York, NY, US, vol. 44, Jul. 2003, pp. 1116-1117. XP008070220.
Bigner Darell D
Kuan Chien-Tsun
Pastan Ira H
Banner & Witcoff , Ltd.
Duke University
Sang Hong
The United States of America as represented by the Secretary of
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