Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-05-12
1998-02-24
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 7021, 5303871, 5303879, 5303881, 5303891, 5303911, 5303913, C12N 512, A61K 39395
Patent
active
057211302
ABSTRACT:
Processing of .beta.-amyloid precursor protein (.beta.APP) is monitored by detecting the secretion of a soluble .beta.APP fragment resulting from cleavage of .beta.APP at the amino-terminus of .beta.-amyloid peptide. In vivo monitoring of secretion of the .beta.APP fragment may be monitored for diagnosis and prognosis of Alzheimer's disease and other .beta.-amyloid-related diseases, while in vitro monitoring of such secretion from cultured cells may be monitored to identify inhibitors of .beta.-amyloid production. The .beta.APP fragment may be detected using antibodies and other specific binding substances which recognize a carboxy-terminal residue on the fragment.
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Fritz Lawrence C.
Schenk Dale B.
Seubert Peter A.
Allen Marianne P.
Athena Neurosciences, Inc.
Duffy Patricia A.
Duvall Jean
Eli Lilly and Company
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