Antibodies against T cell immunoglobulin domain and mucin...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S130100

Reexamination Certificate

active

08067544

ABSTRACT:
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

REFERENCES:
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patent: 2004/0162413 (2004-08-01), Watkins et al.
patent: WO 2004/084823 (2004-10-01), None
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Mueller et al. PNAS vol. 89 pp. 11832-11836, Dec. 1992.
International Search Report for PCT/US06/44090, mailed Apr. 25, 2007.

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