Antibodies against secreted protein HTEBYII

Details Antibodies against secreted protein HTEBYII Antibodies against secreted protein HTEBYII

2005-10-04

2005-10-04

Chan, Christina (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387300, C530S388100, C530S389100, C530S391300, C435S326000, C435S328000, C435S331000, C435S332000

Reexamination Certificate

active

06951924

ABSTRACT:
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

REFERENCES:
patent: 6294648 (2001-09-01), Delaria et al.
patent: 1 033 401 (2000-09-01), None
patent: WO-99/06549 (1999-02-01), None
patent: WO-00/09709 (2000-02-01), None
Laskowski et al., “Protein inhibitors of proteinases,” Annu. Rev. Biochem. 49:593-626 (1980).
Skern et al., “Protease or protease inhibitor?,” Nature 344:26 (Mar. 1, 1990).
Richardson et al., “Cloning and sequencing of human Eppin: A novel family of protease inhibitors expressed in the epididymis and testis,” Gene 270(1-2):93-102 (May 30, 2001).
GenBank Accession No. CAB37635, Clark, L., dJ461P17.2.1 (Eppin-1, Eppin-3 (WAP-type (Whey Acid Protein) ‘four-disulfide core’ domain and a Kunitz/Bovine pancreatic trypsin inhibitor domain protein)) [Homo sapiens]. (Apr. 7, 2001).
Swiss-Prot Accession No. Q9BDL1, Sivashanmugam et al., “Characterization of monkey and mouse Eppin, a protease inhibitor from epididymis and testis.” (Feb. 2003).
GenBank Accession No. CAC36265, Clark, L., “dJ461P17.2.2 (Eppin-2 (WAP-type (Whey Acidic Protein) four-disulfide core” domain and a Kunitz/Bovine pancreatic trypsin inhibitor domain protein)) [Homo sapiens]. (Apr. 7, 2001).
GenBank Accession No. BF057305, “7k18h11.x1 NCI_CGAP_GC6Homo sapienscDNA clone IMAGE:3444741 3′ similar to TR:095925 095925 DJ461P17.2;, mRNA sequence” (Oct. 16, 2000).
GenBank Accession No. BI829722, “603079786F1 NIH_MGC_119Homo sapienscDNA clone IMAGE:5171493 5′, mRNA sequence” (Oct. 4, 2001).
GenBank Accession No. BI828181, “603073650F1 NIH_MGC_119Homo sapienscDNA clone IMAGE:5165509 5′, mRNA sequence” (Oct. 4, 2001).
GenBank Accession No. NM020398, Clauss et al., “Homo sapiensserine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) (SPINLW1), transcipt variant 1, mRNA” (Sep. 6, 2003).
GenBank Accession No. AL031663, Clark, L., “Human DNA sequence from clone RP3-461P17 on chromosome 20q12-13.2. Contains two novel genes, gene HE4 for Major Epididymis-specific protein E4 precursor (Epididymis Secretory protein E4), RPL5 (60S Ribosomal Protein L5), COX6C (Cytochrome C Oxidase subunit VIC) and HSPD1 (HSP60, Mitochondrial Matrix Protein P1 precursor, Heat Shock Protein 60, Groel, HUCHA60) pseudogenes, the SPINT3 gene for Kunitz type serine protease inhibitor 3 (HKIB9), two genes for novel Kunitz/Bovine pancreatic trypsin inhibitor and WAP-type (Whey Acidic Protein) ‘four-disulfide core’ domains containing proteins and the gene for Eppin-1, -2 and -3. Contains ESTs, STSs, GSSs and a CpG island, complete sequence” (Apr. 7, 2001).

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