Antibodies against human IL-22 and uses therefor

Details Antibodies against human IL-22 and uses therefor Antibodies against human IL-22 and uses therefor

2011-03-08

2011-03-08

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S141100, C530S388100, C530S388150, C530S388230, C530S389200

Reexamination Certificate

active

07901684

ABSTRACT:
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.

REFERENCES:
patent: 5350836 (1994-09-01), Kipchick et al.
patent: 5536637 (1996-07-01), Jacobs
patent: 5674487 (1997-10-01), Smith et al.
patent: 5837232 (1998-11-01), De Waal Malefyt et al.
patent: 5863796 (1999-01-01), Moore et al.
patent: 6143867 (2000-11-01), Akerblom
patent: 6225117 (2001-05-01), Gately et al.
patent: 6274710 (2001-08-01), Dumoutier et al.
patent: 6331613 (2001-12-01), Dumoutier et al.
patent: 6359117 (2002-03-01), Dumoutier et al.
patent: 6551799 (2003-04-01), Gurney et al.
patent: 6939545 (2005-09-01), Jacobs et al.
patent: 7279559 (2007-10-01), Jacobs et al.
patent: 7307161 (2007-12-01), Jacobs et al.
patent: 7459533 (2009-12-01), Jacobs et al.
patent: 2001/0006637 (2001-07-01), Akahoshi et al.
patent: 2001/0023070 (2001-09-01), Ebner et al.
patent: 2001/0024652 (2001-09-01), Dumoutier et al.
patent: 2002/0012669 (2002-01-01), Presnell et al.
patent: 2002/0102723 (2002-08-01), Gurney et al.
patent: 2002/0177165 (2002-11-01), Ashkenazi et al.
patent: 2002/0187523 (2002-12-01), Tang et al.
patent: 2003/0003545 (2003-01-01), Ebner et al.
patent: 2003/0012788 (2003-01-01), Renauld et al.
patent: 2003/0092133 (2003-05-01), Ebner et al.
patent: 2003/0170823 (2003-09-01), Presnell et al.
patent: 2004/0023341 (2004-02-01), Xu et al.
patent: 2004/0110189 (2004-06-01), Dumoutier et al.
patent: 2004/0152125 (2004-08-01), Presnell et al.
patent: 2004/0180399 (2004-09-01), Renauld et al.
patent: 2005/0042220 (2005-02-01), Li et al.
patent: WO 94/01548 (1994-01-01), None
patent: WO 99/61617 (1999-12-01), None
patent: WO 00/24758 (2000-05-01), None
patent: WO 00/70049 (2000-11-01), None
patent: WO 00/73457 (2000-12-01), None
patent: WO 00/77037 (2000-12-01), None
patent: WO 01/46422 (2001-06-01), None
patent: WO 02/10393 (2002-02-01), None
patent: WO 02/16611 (2002-02-01), None
patent: WO 02/068476 (2002-09-01), None
patent: WO 2005/000897 (2005-01-01), None
Mikayama et al. Proc. Natl. Acad. Sci. USA (1993) vol. 90, pp. 10056-10060.
Voet et al. Biochemistry John Wiley & Sons, Inc., (1990) pp. 126-128 and 228-234.
Rudikoff et al. Proc. Natl. Acad. Sci. USA vol. 79, pp. 1979-1983 (Mar. 1982).
“Anti-Mouse IL-22 Antibody”, Internet Citation, Aug. 22, 2002, XP-002307633.
International Preliminary Report on Patentability (1 page).
Written Opinion of the International Searching Authority (9 pages).
Sugimoto et al. Gastroenterology: 2006: 130; 4: Suppl. 2: A41.
Sugimoto et al. Gastroenterology: 2005: 128: Suppl. 2: A18.
Van Deventer et al. Reaserach and Clinical Forums. 1998; 20; 11-18.
Andoh et al., “Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts”, Gastroenterology: 2005 129:969-84.
Brand et al. Am. J. Physiol. Gastrointest. Liver Physiol.: 2006: 290:G827-38.
Sugimoto et al., “IL-22 Ameliorates intestinal inmflammation in a mouse model of ulcerative colitis”, The Journal of Clinical Investigation: 2008: 118:534-44.
Mahairas G. et al., Database Est. Accession No. AQ104025. Aug. 1998.
Waterston R. et al., Database GenEmbl. Accession No. AC006734. Feb. 25, 1999.
Wilson R. et. al. J. Mol. Biol. 261:155-172,1996.
Bork et al., Trends in Genetics 12:425-427, 1996.
Vukicevic et al., PNAS USA 93:9021-26, 1996.
Massague, J. Cell 49:437-8, 1987.
Pilbeam et al., Bone 14:717-720, 1993.
Skolnick et al., Trends in Biotech. 18:34-39, 2000.
Dumoutier, L. et al., (2000), J. of Immunol. 164:1814-1819.
Syrbe et al., (1999) Springer Seminars in Immunopathology, 21:263-85.
Dumoutier, L. et al., GenBank Accession NO NM—016971 forMus musculusinterleukin 10-related T cell-derived inducible factor (Iltif). Jun. 8, 2000.
Aoki, I., et al Comparison of the amino acid and nucleotide sequences between human and two guinea pig major basic proteins,: FEBS Lett. 282(1):56-60, 1991.
Dumoutier, L. et al., PNAS 97(18):10144-9,2000.
Dumoutier, L. et al., “IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes,” Genes Immun. 1:488-494, 2000.
Ozaki, T. et al. GenBank Accession No. D13973 for Dictyostelium discoideum DNA for Dp87 protein, 1993. Feb. 1, 2000.
Aoki, I., et al. GenBank Accession No. P35709 for Eosinophil granule major basic protein 2 precursor (mbp-2). May 30, 2000.
Xie, M. et al. GenBank Accession No. AF279437 forHomo sapiensinterleukin 22 (IL22). Oct. 9, 2000.
Dumoutier, L., et al., GenBank Accession No. AJ294727 forMus musculusILTIFa gene for IL TIE alpha protein (LI-21), exons la. Dec. 21, 2000.
Dumoutier, L., et al., GenBank Accession No. NP—065386 for Interleukin 22; Interleukin 21; IL-10-related T-cell-derived inducible factor (Homo sapiens). Nov. 2, 2000.
Ozaki, T., et al., Developmental regulation of transcription of a novel prespore-specific gene (Dp87) in Dictyostelium doscoideum,: Development. 117(4):1299-308, 1993.
Sambrook, J. et al., Molecular Cloning. A Laboratory Manual, 2d ed. Cold Spring Harbor Laboratory Press, 1989, Ch. 17.
Xie, M. et al., J. Biol. Chem. 275(40):31335-9, 2000.
Kotenko, Sergei V. et al., Journal of Biological Chemistry, American Society of Biological Chemists, Baltimore, MD, US, vol. 276, No. 4, Jan. 26, 2001, pp. 2727-2732.
Dumoutier, L. et al., “IL-TIF induces acute phase reactant production by heatocytes through IL-10Rbeta.” Immunology Letters, vol. 73, No. 2-3 Sep. 2000, p. 261.
Lambert, A. et al., Toxicologic Pathology, vol. 29, No. 6, Nov. 2001, p. 712.
Bork, P., Genome Research 10:398-400, 2000.
Doerks, et al., Trends in Genetics 14:248-250, 1998.
Smith, et al., Nature Biotechnology 15:1222-1223, 1997.
Brenner, S. E., Trends in Genetics 15:132-133, 1999.
Mahairas, et al., PNAS, USA, 96(17) 739-9744 (1999).
Simon L.S., et al., (Jun. 2000), New and future drug therapies for rheumatoid arthritis, Rheumatology 39: 36-42.
Llorente L., et al. (2000) Arthritis and Rheumatism 43(8): 1790-1800.
Van Den Berg W. (1998), Joint inflammation and cartilage destruction may occur uncoupled, Springer Semin Immunopathol. 20:149-164.
Kotenko, Sergei, Cytokine and Growth Factor Reviews, vol. 13, No. 3, Jun. 2002, pp. 223-240.
Radaeva, Svetlana, et al., Hepatology, vol. 39, No. 5, May 2004, pp. 1332-1342.
Resmini, C., et al., European Cytokine Network, vol. 14, No. Sup. 3, Sep. 2003, p. 129 and Annual Meeting of Int'l Cytokine Society; Dublin, Sep. 20-24, 2003. ISSN:1448-5493.
Li, J., et al, International Immunopharmacology, Elsevier, Amsterdam, NL, vol. 4, No. 5, May 2004, pp. 693-708.
Amelizad Z et al. Accession No. A60822, Biochem. Pharmacol. 37, 3245-3249, 1988.
International Search Report from PCT/US2007/004692.
International Report on Patentability and Written Opinion of the International Searching Authority for PCT/US2007/004692.
International Search Report from PCT/US2007/004430.
Paul, Fundamental Immunology, 3d Edition, 1993, pp. 292-295.
Lederman et al., Molecular Immuology, 1991. vol. 28, pp. 1171-1181.
Li et al., Proc Natl Aca Sci USA, 1980. vol. 77, pp. 3211-3214.
Daniel at al., Virolgy, 1994. vol. 202, pp. 540-549.
Communication Pursuant to Article 94(3) EPC dated Nov. 10, 2009 from European Patent Application No. 07 751 204.4.

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