Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1998-02-19
2000-04-18
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241331, 4241411, 4241431, 4241531, 4241731, 4352523, 4353201, 435452, 5303871, 5303873, 5303882, 53038822, 5303887, 53038873, 536 2353, A61K 39395, C07K 1628, C12N 1513, C12N 121
Patent
active
060512288
ABSTRACT:
The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.
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Aruffo Alejandro A.
Bajorath Jurgen
Berry Karen K.
Harris Linda
Hollenbaugh Diane
Bristol-Myers Squibb Co.
Chan Christina Y.
Gambel Phillip
Klein Christopher A.
Sher Audrey F.
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