Antibodies against highly conserved amino acid sequences of insu

Details Antibodies against highly conserved amino acid sequences of insu Antibodies against highly conserved amino acid sequences of insu

1994-09-16

1996-05-07

Scheiner, Toni R.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 79, 435 792, 435968, 436 87, 436811, 436817, 530303, 5303879, G01N 33543, G01N 3368, G01N 3374

Patent

active

055145990

ABSTRACT:
Antibodies against highly conserved amino acid sequences of immunogenic substances, a process for the preparation of these antibodies and the use thereof in immunoassays.
The invention relates to antibodies which are obtained by immunization with a peptide fragment which represents a highly conserved amino acid sequence of a native protein. The antibodies according to the invention can be used for the preparation of immunoassays, in particular for the preparation of assays for the determination of genetically engineered products such as insulin which arise as sparingly soluble inclusion bodies in microorganisms. The invention particularly relates to a multispecies insulin assay in the form of an RIA.

REFERENCES:
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patent: 4981782 (1991-01-01), Judd et al.
patent: 5070025 (1991-12-01), Klein et al.
Kato, K. "Insulin" in Methods of Enzymatic Analysis, Third Edition, 1986.
H. U. Bergmeyer, ed. vol. IX Proteins and peptides pp. 451-462.
Leslie F. Smith, Ph.D. "Amino Acid Sequences of Insulins", Diabetes 21 (Suppl. 2):457-60, 1972.
D. Plachov et al., "The specificity of the interaction between the agretope of an antigen and an la-molecule can depend on the T cell clonotype", Biol. Abs. 86(10), No. 103111 (1988).
A. Marks et al., "Characterization of two epitopes on insulin using monoclonal antibodies", Chem. Abs. 102(21):179524y (1985).

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