Antibodies against fibrin; immunogenic peptides suitable for pre

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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424 88, 530382, 53038825, 5303893, C07K 1528, A61K 3900, A61K 39395

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active

051244390

ABSTRACT:
Antibodies are provided which are directed against a sequence of amino acids corresponding to amino acids from the sequence 311-379 in particular 311-336 of the .gamma.-chain of fibrinogen. These novel antibodies react specifically with fibrin, both type I and type II. They are effective in detecting, preventing and treating blood clot formation.

REFERENCES:
patent: 4916070 (1990-04-01), Matsueda et al.
Fair et al. (1981) J. Biol. Chem. 256, 8018-8023.
Wilner et al. (1982) Biochemistry 21, 2687-2692.
Chung et al. (1983) Biochemistry 22, 3250-3256.
Houranieh et al. (1988) Hybridoma 7, 55-68.
Abstract 6480 from the FASEB Journal.

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