Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-05-04
1992-03-24
Kepplinger, Esther L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530382, 530330, 53038825, 5303893, 436518, 436548, 435 13, C07K 1300, C12Q 156
Patent
active
050990047
ABSTRACT:
Antibodies are provided, which are directed against a sequence of amino acids corresponding to amino acids from the sequence 111-207, in particular 148-161, of the A.alpha.-chain of fibrinogen. These novel antibodies react specifically with fibrin, both type I and type II, and not with fibrinogen. They are effective in detecting, preventing and treating blood clot formation.
REFERENCES:
patent: 4722903 (1988-02-01), Kudryk et al.
patent: 4851334 (1989-07-01), Kudryk et al.
patent: 4927916 (1990-05-01), Matsueda et al.
Hui et al., Science, vol. 222, pp. 1129-1132, 1983.
Nieuwenhuizen et al., Fibrinogen-Fibrin Formation and Fibrinolysis, vol. 4, pp. 145-192, 1986.
Nieuwenhuizen et al., Biochim. Biophys. Acta, vol. 748, pp. 86-92, 1983.
Nieuwenhuizen et al., Biochim. Biophys. Acta, vol. 755, pp. 531-533, 1983.
Voskuilen et al., Journal of Biological Chemistry, vol. 262, pp. 5944-5946, 1987.
Matsueda et al., Biochemistry, vol. 25, pp. 1451-1455, 1986.
Hui et al., Hybridoma, vol. 5, pp. 215-222, 1986.
Scheefers-Borchel et al., Proc. Natl. Acad. Sci. USA, vol. 82, pp. 7091-7095, 1985.
Liau et al., Thrombosis and Hematosis, vol. 57, pp. 49-54, 1987.
Biological Abstracts, vol. 76, No. 10, Abstract No. 69866, 1983.
Chemical Abstracts, vol. 107, No. 5, Aug. 3, 1987, p. 359, Abstract No. 36045K.
Kudryk et al., Molecular Immunology, vol. 21, No. 1, pp. 89-94, 1984.
Chemical Abstracts, vol. 103, No. 17, Oct. 28, 1985, Abstract No. 139994R.
Roitt, I., Essential Immunology, Sixth Edition (Blackwell Scientific Publications, Boston), pp. 55-56 (1988).
W. Schielen et al., "The sequence A.alpha.-(148-160) in fibrin, but not in fibrinogen, is accessible to monoclonal antibodies", Proc. Natl. Acad. Sci. USA, vol. 86, pp. 8951-8954, Nov. 1989.
Kepplinger Esther L.
Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk On
Spiegel Carol A.
LandOfFree
Antibodies against fibrin: immunogen to be used for the preparat does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies against fibrin: immunogen to be used for the preparat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies against fibrin: immunogen to be used for the preparat will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2011409