Antibodies against epitopes with homology to self antigens,...

Details Antibodies against epitopes with homology to self antigens,... Antibodies against epitopes with homology to self antigens,...

2006-10-10

2006-10-10

Wehbé, Anne M (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal to manufacture...

The protein is isolated or extracted from blood or serum

C800S004000, C800S013000, C800S018000, C800S021000, C424S184100, C530S387100, C530S388100, C435S326000

Reexamination Certificate

active

07119248

ABSTRACT:
This invention provides novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof. The method involves obtaining a genetically engineered host animal that does not biosynthesize at least one epitope of the antigen and utilizes the lack of self-tolerance of the host to the epitope to produce antibodies specific to the antigen. The invention also encompasses the AMABs produced by the methods. The invention further encompasses methods of isolating cells comprising the use of such AMABs that have specificity for a cell surface antigen.

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