Antibodies against creatinekinase-M8 and process for the product

Details Antibodies against creatinekinase-M8 and process for the product Antibodies against creatinekinase-M8 and process for the product

1979-05-08

1980-12-02

Fagelson, Anna P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

23230B, 260112R, 424 8, 424 12, 424 85, A61K 39395, C07G 700, G01N 3368

Patent

active

042370442

ABSTRACT:
Antibodies against the M subunit of CK isoenzymes having a molecular weight between about 130,000 and 210,000, and inhibiting the enzymatic activity of the M subunit, optionally also in the presence of CK substrates, without inactivating the enzymatic activity of the B subunit of any CK-MB which may be present, are described. A process for the production of these antibodies comprises inoculating animals with activated CK-MM and recovering the antibodies in a conventional manner.

REFERENCES:
patent: 3932221 (1976-01-01), Pfleiderer
patent: 4012285 (1977-03-01), Pfleiderer
patent: 4067775 (1978-01-01), Wurzburg
Mercer, Clin Chem vol. 20, No. 1, 1974 pp. 36-40.
Pfleiderer, Clin Chem Acta, vol. 58 No. 3, 1975 pp. 223-232.
Henry, Clin Chem, vol. 21, No. 7, 1975 pp. 844-848.
Roy, Biochem J vol. 143, 1974 pp. 171-179.
Eppenberger, J. Biol. Chem., vol. 242, 1967 pp. 204-209
Armstrong, Diss. Ab, vol. 36, No. 10 (B) p. 4987-B.
Williams, Methods in Immunol. & Immunochem. Acd Press, NY vol. I, 1967 pp. 205-221, 237-244.
Dawson, J of Biol. Chem. vol. 242, 1967 pp. 210-217.
Wurzburg, J Clin. Chem. Clin. Biochem; vol. 15, 1977 pp. 131-137.

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