Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2005-07-08
2009-10-06
Canella, Karen A (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S007100, C435S007210, C435S069600, C435S070100, C435S070200, C435S070210
Reexamination Certificate
active
07598030
ABSTRACT:
This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for identifying antibodies which bind to cancer cells, but which do not bind to human red or white blood cells or normal tissue cells. Antibodies of the disclosure can be used for therapeutic and/or diagnostic purposes.
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Freeman, J.W., et al., “Masking of nontumorous antigens for development of human tumor nucleolar antibodies with improved specificity,” Cancer Research, 45(11 Pt 2):5637-5642 (1985).
Su, Z-Z., et al., “Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-I a member of the galactin gene family,” Proc. Natl. Acad. Sci. USA, 93:7252-7257 (Jul. 1996).
Bowdish Katherine S.
Dakappagari Naveen
Maruyama Toshiaki
Xin Hong
Alexion Pharmaceuticals, Inc.
Canella Karen A
Ropes & Gray LLP
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