Antibodies against cancer produced using masked cancer cells...

Details Antibodies against cancer produced using masked cancer cells... Antibodies against cancer produced using masked cancer cells...

2005-07-08

2009-10-06

Canella, Karen A (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S007100, C435S007210, C435S069600, C435S070100, C435S070200, C435S070210

Reexamination Certificate

active

07598030

ABSTRACT:
This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for identifying antibodies which bind to cancer cells, but which do not bind to human red or white blood cells or normal tissue cells. Antibodies of the disclosure can be used for therapeutic and/or diagnostic purposes.

REFERENCES:
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patent: 2003/0219821 (2003-11-01), Fisher et al.
patent: WO95/06124 (1995-03-01), None
patent: WO-96/21671 (1996-07-01), None
patent: WO96/21671 (1996-07-01), None
patent: WO96/40173 (1996-12-01), None
patent: WO03/019137 (2003-03-01), None
patent: WO-03/028625 (2003-04-01), None
Freeman, J.W., et al., “Masking of nontumorous antigens for development of human tumor nucleolar antibodies with improved specificity,” Cancer Research, 45(11 Pt 2):5637-5642 (1985).
Su, Z-Z., et al., “Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-I a member of the galactin gene family,” Proc. Natl. Acad. Sci. USA, 93:7252-7257 (Jul. 1996).

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