Antibiotics X-14889 A,C and D

Details Antibiotics X-14889 A,C and D Antibiotics X-14889 A,C and D

1985-05-23

1987-06-09

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435119, 435169, 435886, 435905, C12P 1960, C12P 1718, C12P 106, C12R 1465, C12R 160

Patent

active

046720332

ABSTRACT:
There is presented antibiotic compounds designated as Antibiotics X-14889 A, C and D of the formulas ##STR1## wherein (for X-14889A) R.sub.1 is methyl, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.4 is methyl and R.sub.5 is hydrogen or (for X-14889C) R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.4 is methyl and R.sub.5 is CO.sub.2 H or ##STR2## and the pharmaceutically acceptable salts thereof. The compounds exhibit antimicrobial activity and one of the compounds X-14889C also exhibits activity against Treponema hyodysenteriae (in vitro), Plasmodium berghei and as food efficiency enhancers in ruminants.
Also presented is a process to produce the above compounds and another known component Antibiotic X-14889B.

REFERENCES:
patent: 4161520 (1979-07-01), Osborne et al.
patent: 4174404 (1979-11-01), Nakatsukasa et al.
patent: 4368265 (1983-01-01), Liu et al.
patent: 4407946 (1983-10-01), Labeda et al.
patent: 4601984 (1986-07-01), Liu et al.
Journal of Antibiotics, vol. 30, No. 2, pp. 186-188, Feb. 1977.

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