Antibiotics and process for production thereof

Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis

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424115, 435169, A61K 3500

Patent

active

042833906

ABSTRACT:
Antibiotic A-39183 complex, comprising microbiologically active, related factors A, B, C, D, and E, is produced by submerged, aerobic fermentation of a new microorganism Streptomyces sp., NRRL 12049. The A-39183 antibiotics are closely related antibiotics. The individual A-39183 factors are separated by chromatography. The A-39183 factors are antibacterial agents which have activity against Staphylococcus and Streptococcus species that are penicillin resistant. The A-39183 factors are also active against both gram-positive and gram-negative anaerobic bacteria, and are ionophores.

REFERENCES:
patent: 3769418 (1973-10-01), Prelog et al.
Hutter et al., Helve. Chim. Act 50, pp. 1533-1539 (1967).
Dunitz et al. Helve Chim. Act. 54, pp. 1709-1713 (1971).
Derwent Farmdoc, Abstracting Japan Pat. No. 76154B/42, Published 2-28-78.
Omura et al., The J. of Antibiotics, 31, pp. 1091-1093 (1978).

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