Antibiotics aclacinomycins A and B

Details Antibiotics aclacinomycins A and B Antibiotics aclacinomycins A and B

1975-07-16

1976-10-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

195 80R, 424181, 536 4, C07H 1708

Patent

active

039883159

ABSTRACT:
New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as leukemia L1210 and P388 and lymphoma 6C3HED in mice and hepatomas in rats are produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces galilaeus (MA144-M1 and A.T.C.C. 31133); they are recovered from the broth by conventional methods for recovering antibiotics.

REFERENCES:
gottlieb et al., "Antibiotics", vol. I, Springer-Verlag, New York, 1967, pp. 190-204.
Berg, et al. "Chem. Abst." vol. 73, 1970, pp. 54,265r.
Keller-Schierlein et al. "Antimicrobial Agents and Chemotherapy", 1970, pp 68-74.

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