Antibiotics AA-896

Details Antibiotics AA-896 Antibiotics AA-896

2002-04-25

2004-02-10

Fonda, Kathleen K. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S049000, C536S028400, C536S028530

Reexamination Certificate

active

06689763

ABSTRACT:

BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA896-A6, AA-896-B1, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-896-D2, AA-896-D3, and AA-896-D4 to their production by fermentation, to methods for their recovery and concentration from crude solutions and to processes for their preparation. The present invention includes within its scope the agents in dilute form, as crude concentrates, as a complex of all components and in pure form as individual components. Further, the invention includes novel strains of Streptomyces spp. LL-AA896.
2. Description of the Prior Art
Natural products, Liposidomycins A, B and C, have been isolated and reported to have antibacterial activity(Isono, K.; Uramoto, M.; Kusakabe, H.; Kimura, K.; Izaki, K.; Nelson, C. C.; McCloskey, J. A.,
J. Antibiotics,
1985, 38, 1617-1621. Ubukata, M.; Isono, K.; Kimura, K.; Nelson, C. C.; McCloskey, J. A.
J. Am. Chem. Soc.,
1988, 110, 4416-4417. Kimura, K.; Miyata, N.; Kawanishi, G.; Kamino, Y.; Izaki, K.; Isono, K.
Agric. Biol. Chem.,
1989, 53, 1811-1815.). Isolated Liposidomycins A-(I), A-(II), A-(III) and A-(IV) are also reported to have antibacterial activity (Kimura, K.; Ikeda, Y.; Kagami, S.; Yoshihara, M.,
J. Antibiotics,
1998, 51, 1099-1104. and other references herein). The detailed structural analysis of Liposidomycins A, B and C using their chemical degradation products has been reported (Ubukata, M.; Kimura, K.; Isono, K.; Nelson, C. C.; Gregson, J. M.; McClosky, J. A.,
J. Org. Chem.,
1992, 57, 6392-6403). Liposidomycin class compounds are further reported (Patents JP05078385) and are derivatives of 2-methylamino-3-(5-aminomethyl-4-hydroxy-3-hydroxy-tetrahydro-fura-2-yloxy)-3-[3,4-dihyoxy-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)tetrahydro-2-furanyl]propanoic acid or the degraded products of 2-methylamino-3-(5-aminomethyl-4-hydroxy-3-hydroxy-tetrahydro-fura-2-yloxy)-3-[3,4-dihyoxy-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)tetrahydro-2-furanyl]-propanoic acid.


REFERENCES:
patent: 3674886 (1972-07-01), Lindner et al.
patent: 05078385 (1991-02-01), None
Lin, et al. Muraymycins, Novel Peptidolycan Biosynthesis Inhibitors: Semisynthesis and SAR of Their Derivatives. Bioorganic & Medicinal Chemistry Letters, 2002, vol. 12, pp. 2341-2344.
PCT/US02/13218, International Search Report, Jun. 24, 2003.
Isono, K.; Uramoto, M.; Kusakabe, H.; Kirmura, K.; Izaki, K.; Nelson, C.C.; McCloskey, J.A.; J. Antibiotics, 1985, 38, 1617-1621.
Ubukata, M.; Isono, K.; Kimura, K.; Nelson, C.C.; McCloskey, J.A.; J. Am. Chem. Soc., 1988, 110, 4416-4417.
Kimura, K.; Miyata, N.; Kawanishi, G.; Kamino, Y.; Izaki, K.; Isono, K.; Agric. Biol.Chem, 1989, 53, 1811-1815.
Kimura, K.; Ikeda, Y.; Kagami, S.; Yoshihara, M.; J. Antibiotics, 1998, 51, 1099-1104.
Ubukata, M., Kimura, K.; Isono, K.; Nelson, C.C.; Gregson, J.M.; McClosky, J.A.; J.Org.Chem. 1992, 57, 6392-6403.
English Translation of JP05078385, 2-25-91.

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