Antibiotics A6888C and A6888X

Details Antibiotics A6888C and A6888X Antibiotics A6888C and A6888X

1979-05-23

1981-02-24

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

536 17R, 435886, C12P 1962

Patent

active

042528984

ABSTRACT:
Antibiotic compounds of the formula: ##STR1## wherein R' is ##STR2## or --CH.sub.2 OH, and the non-toxic pharmaceutically acceptable acid addition salts thereof, are produced by culturing Streptomyces flocculus NRRL 11459. Techniques for isolating the compounds are also described. Cirramycin A.sub.1 and cirramycin B are coproduced.

REFERENCES:
patent: 3159540 (1964-12-01), Kawaguchi et al.
patent: 3950516 (1976-04-01), Miyaki
Omura et al., J. Antibiotics 28, 401-433, (Jun. 1975).
Keller-Schierlein in Fortschrittee der Chemie Organischer Naturstoffe, vol. 30, pp. 314-445, (p. 359 only checked).
Suzuki, Bull. Chem. Soc., Japan, vol. 48, p. 292, (1970).
Tsukira et al., J. Antibiotics, vol. 22, pp. 89-99, (1969).

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