Antibiotics 7(R)-O-alkylnogalarols

Details Antibiotics 7(R)-O-alkylnogalarols Antibiotics 7(R)-O-alkylnogalarols

1979-10-31

1980-12-09

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424278, C07D31908

Patent

active

042383986

ABSTRACT:
Novel antibiotics, 7(R)-0-alkylnogalarols, prepared by acidic alcoholysis of nogalamycin of nogalarol, which are active against various microorganisms, for example, Bacillus subtilis, Streptococcus pyogenes, Sarcina lutea, Bacteroides fragilis, Clostridium perfringens, and Mycobacterium avium. Thus, they can be used to inhibit the growth of the above microorganisms in various environments. Further, the invention compounds possess unexpected superior activity against P388 leukemia infection in laboratory mice. Thus, the compounds of the invention can be used to treat laboratory mice infected with P388 leukemia.

REFERENCES:
patent: 3183157 (1965-05-01), Bhuyan et al.
patent: 3501569 (1970-03-01), Wiley et al.
patent: 4086245 (1979-04-01), Wiley et al.

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