Antibiotics 10381v, w, x,y, z1, z2, pre-b and t

Details Antibiotics 10381v, w, x,y, z1, z2, pre-b and t Antibiotics 10381v, w, x,y, z1, z2, pre-b and t

1996-03-07

1998-04-07

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530317, 530323, 424117, 424118, 426635, 435 713, 435170, 435822, A61K 3702, A61K 3574, C07K 754, C12P 2100

Patent

active

057365105

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

This invention relates to antibiotics designated as 10381v, w, x, y, z1, z2, pre-b and t, which are isolated from crude extracts of fermentation beers of the microorganism, Streptomyces arginensis.


BACKGROUND

The isolation, purification, physicochemical and biological properties of three sulfur-containing peptidic antibiotics, sulfomycin I, II and III, are disclosed in J. Antibiotics, 22(1): 12-22 (1969). Tetrahedron Lett., 29(12): 1401-4 (1988), discloses the structure of sulfomycin I, a modified peptide antibiotic. A revised structure of the structurally related antibiotic, berninamycin A, was also proposed. Tetrahedron Lett., (31): 2791-4 (1978), discloses methanolysis products of sulfomycin I. Tetrahedron Lett., (9): 735-6 (1977), discloses acid hydrolysis products of sulfomycin I.
Chemical Abstracts 73(1): 2666c (Japanese Patent 45006880) discloses the preparation of sulfomycin I by the cultivation of Streptomyces viridochromogenes var sulfomycini. U.S. Pat. No. 4,007,090 discloses and claims a novel fermentation process for the preparation of sulfomycin I from the microorganism Streptomyces cineroviridis. Chemical Abstracts 73(17): 86558e (Japanese Patent 45017588) discloses the preparation of Sulfomycins II and III by the cultivation of Streptomyces viridochromogenes var sulfomycini. Their uv and antibiotic spectra were similar to those of sulfomycin I.
J. Antibiotics, 45(11): 1809-1811 (1992), and European patent application 0 274 873, published 20 Jul. 1988, disclose A10255, a thiopeptide antibiotic complex, which contains a cyclic peptide core with an amino acid side chain. J. Antibiotics, 42(10): 1465-9 (1089), discloses the isolation and characterization of thioxamycin, a peptide antibiotic.


INFORMATION DISCLOSURE

The production and properties of the 10381b antibiotic complex are described in International Publication Number WO 88/00200, dated 14 Jan. 1988. According to this publication, the 10381b antibiotic complex is produced by fermentation of a nutrient medium with the microorganism Streptomyces arginensis. Furthermore, this publication stated that the 10381b complex comprises a group of at least five antibacterial agents active mainly against Gram-positive organisms and having physical properties similar to those reported for the sulfomycin group of antibiotics. The main components of the 10381b complex were designated 10381b.sub.2 and 10381b.sub.3. Of these two components, 10381b.sub.2 was isolated in sufficient quantity and purity to permit biological and chemical characterization. The structure of 10381b.sub.2 was thought to be identical to the peptide antibiotic sulfomycin I from Streptomyces viridochromogenes; this has since been confirmed. The 10381b antibiotic complex displays antimicrobial activity against Gram-positive bacteria and is useful as a growth, promotant for meat-producing animals, such as poultry, swine and cattle. However, this publication does not teach or disclose the isolation or identification of other components of the 10381b antibiotic complex, especially Antibiotics 10381v, w, x, y, z1, z2, pre-b and t of the present invention.
The production and properties of arginomycin (antibiotic 10381a.sub.1) are described in International Publication Number WO86/05785, dated 9 Oct. 1986, and in A. D. Argoudelis et al., The Journal of Antibiotics, XL (6):750-760, June 1987.
None of the references in this field known to Applicant teaches or suggests Antibiotics 10381v, w, x, y, z1, z2, pre-b and t of the present invention.


SUMMARY OF THE INVENTION

The present invention particularly provides: pharmacologically acceptable salts thereof; formula I, II, III, IV, V, VI, VII or IX, or any combination thereof;
An animal premix, which comprises a compound of the formula I, II, III, IV, V, VI, VII or IX, or any combination thereof, and a suitable inert carrier therefor; and the animals an effective amount of a compound of the formula I, II, III, IV, V, VI, VII or IX, or any combination thereof.
The detection, isolation and identification of these ant

REFERENCES:
patent: 5229362 (1993-07-01), Kirst et al.
A.D. Argoudelis et al., The Journal of Antibiotics, XL (6):750-760, Jun. 1987.
DeBono et al.; The Structures of A10255B,-G, and J:New Thiopeptide Antibiotics Produced By Streptomyces gardner; The Journal of Organic Chemistry; 57(19) Sep. 11, 1992 5200-5208.

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