Antibiotically active rifamycin derivatives

Details Antibiotically active rifamycin derivatives Antibiotically active rifamycin derivatives

1979-04-19

1981-04-14

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424854;246, C07D52100

Patent

active

042618916

ABSTRACT:
Antibiotically active compounds derived from rifamycin S or from the corresponding hydroquinone, rifamycin SV, or from derivatives at least partially hydrogenated in positions 16, 17; 18, 19; 28, 29, such as the 16, 17; 18, 19-tetrahydro-or the 16, 17; 18, 19; 28, 29-hexahydro derivatives, which contain in position 3 a free or an aliphatically substituted amino group. The hydrocarbon radicals of the aliphatically substituted amino group can also be interrupted in their carbon chain by heteroatoms and/or be substituted by functional groups.
A special group of these new compounds is represented by 3-amino derivatives as defined above, in which the amino group is a particular type of N-aza-cyclo-aliphatic radical unsubstituted by functional groups, and which has, in addition to the antibiotic action against sensitive microorganisms also an antibacterial activity against certain types of resistant microorganisms.
Another special group is represented by 3-amino derivatives as defined above, in which the amino group is a particular type of a 4R-1-piperazinyl radical, in which R is a hydrocarbon radical; they have a special high antituberculosis action, while having very low toxicity.

REFERENCES:
patent: 4005077 (1977-01-01), Bicket et al.

Affiliated with

Also associated with

Rating

Antibiotically active rifamycin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotically active rifamycin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotically active rifamycin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-158236