Antibiotic WAP-8294A, method for preparing the same and antibact

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

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A61K 3800

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active

056484550

ABSTRACT:
Antibiotics WAP-8294A, A.sub.1, A.sub.2, A.sub.4, AX, AX-8, AX-9 and AX-13 or pharmeceutically acceptable salts thereof produced by a strain belonging to the genus Lysobacter; a method for producing the foregoing antibiotic WAP-8294A comprising the steps of cultivating, in the culture medium, a microorganism belonging to the genus Lysobacter and having an ability of producing the antibiotic WAP-8294A to produce the antibiotic and accumulate it in the culture medium; then recovering the antibiotic; as well as an antibacterial composition comprising the antibiotic or pharmaceutically acceptable salts thereof are herein disclosed. The novel antibiotic WAP-8294A has an excellent therapeutic effect on infectious diseases developed by infection with Gram-positive bacteria, in particular, MRSA and, therefore, the antibiotic is effective for treating diseases including MRSA infectious diseases developed through infection with Gram-positive bacteria as infectious bacteria.

REFERENCES:
patent: 4754018 (1988-06-01), Tymiak et al.
patent: 4876251 (1989-10-01), Morimoto et al.
patent: 4891427 (1990-01-01), Morimoto et al.

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