Antibiotic trienomycins and their production

Details Antibiotic trienomycins and their production Antibiotic trienomycins and their production

1986-01-27

1992-04-28

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

435121, 514183, C07D22506, C12P 1710, A61K 31395

Patent

active

051091330

ABSTRACT:
Novel compounds of the formula ##STR1## wherein R is hexahydrobenzoyl, isovaleryl or 2-methylbutyryl, and pharmaceutically acceptable salts thereof. The novel compounds designated as Trienomycins A, B and C are produced by culturing a microorganism belonging to genus Streptomyces, specifically Streptomyces sp. 82-16 FERM BP-939 in a medium, accumulating the new compounds in the medium and isolating the new compounds therefrom, and if required converted to a salt thereof. These compounds have antitumor activity and cytocidal activity.

REFERENCES:
patent: 4521339 (1985-06-01), Otake et al.
patent: 4649135 (1987-03-01), Otake et al.
"Studies on Mycotrienin Antibiotics, a Novel Class of Asamycins", The Journal of Antibiotics, vol. 35, No. 11 Nov., 1982, pp. 1460-1466.
"Communications to the Editor", The Journal of Antibiotics, vol. 36, No. 2, Feb., 1983, pp. 187-189.

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