Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1986-01-31
1988-07-26
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
435169, A61K 3574, C12P 106
Patent
active
047599286
ABSTRACT:
Two strains of Streptomyces were identified as Streptomyces albovinaceous. Both isolates produced an antibiotic when grown in liquid culture medium containing homogenized oats. The antibiotic (Treponemycin) was isolated from the culture broth by solvent extraction and purified. The antibiotic showed inhibitory activity against several species of bacteria, especially Treponema hyodysenteriae, the causative agent of swine dysentery. In view of the oral 50% lethal dose of 400 mg/kg and its low MIC against four strains of T. hyodysenteriae, the antibiotic has value as a swine dysentery therapeutic. The antibiotic lends itself readily to production of a tetrahydro derivative, a primary amine, a dimethyl ester and a hydrochloride esters and salts of these compounds, and hydrates of these compounds and of the esters or salts can also be produced for pharmaceutical usages.
REFERENCES:
patent: 2999048 (1961-09-01), Donovick et al.
Chemical Abstracts 103: 50922t (1985).
S. K. Singh, S. Gurusiddaiah, and J. W. Whalen, 1985, Treponemycin, A Nitrile Antibiotic Active Against Treponema hyodysenteriae, Antimicrobial Agents and Chemotherapy, 27, 239-245.
L. Anderton and R. W. Rickards, 1965, Some Structural Features of Borrelidin, An Antiviral Antibiotic, Nature: 206: p. 269.
T. Korzybski, Z. Kowszyk-Ginder, and W. Kurytowicz, 1978, Antibiotics, vol. II, pp. 1198-1199, ASM Publications.
R. M. Silverstein and G. C. Bassler, 1968, Spectrometric Identification of Organic Compounds, p. 256, John Wiley and Sons; New York.
Gurusiddaiah Sarangamat
Singh Shrikrishna
Goldberg Jerome D.
Washington State University Research Foundation
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