Antibiotic TKR2648 and process for producing the same

Details Antibiotic TKR2648 and process for producing the same Antibiotic TKR2648 and process for producing the same

1999-03-26

2001-07-17

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

C549S292000, C435S125000, C435S123000

Reexamination Certificate

active

06261826

ABSTRACT:

TECHNICAL FIELD
The present invention relates to TKR2648, which is an antibiotic of use as a therapeutic agent for fungal infectious diseases, a method for their production, and microorganisms producing said antibiotic.
BACKGROUND ART
Fungi are known to cause a variety of infectious diseases in man, animals, and plants. In man, for instance, they cause superficial mycosis affecting the skin, oral cavity, etc. and systemic mycosis affecting the viscera, brain, etc. They cause similar infections in pet and domestic animals as well. Furthermore, fungi inflict various hazardous effects on plants such as orchard trees and vegetables.
As the principal pathogenic fungi causing systemic mycosis in man, those of the genera Candida, Cryptococcus, and Aspergillus, among others, are known. As to superficial mycosis, Candida species affecting the skin, oral cavity, and vagina and trichophytons infecting the skin of the extremities are regarded as the major pathogenic fungi. Besides those fungi, many other fungi exist in the environment and are suspected to contaminate the animal and vegetable kingdoms.
PROBLEMS TO BE SOLVED BY THE INVENTION
As antimycotics of use for the prevention and treatment of such fungal infections and contaminations, only a very few are known. As therapeutic drugs for systemic mycosis in man and animals, for instance, amphotericin B, flucytosine, miconazole, and fluconazole can be mentioned. However, those compounds are not fully satisfactory in potency, toxic potential, or antifungal spectrum, thus being not impeccable as therapeutic drugs.
In view of the above-mentioned prior art, the present invention has for its object to provide a novel antibiotic which is of value as a therapeutic agent for fungal infections.
MEANS FOR SOLVING THE PROBLEMS
In their search for a novel antibiotic, the inventors of the present invention isolated a large number of microorganisms from the natural kingdom, isolated the antibiotics they produced, and scrutinized their biological properties. As a result, they discovered that the culture broth of a strain of microorganism of the genus Penicillium contained an antibiotic having antifungal activity against pathogenic fungi inclusive of
Candida albicans, Cryptococcus neoformans,
and
Asperaillus fumigatus
. Accordingly the inventors isolated this antibiotic and studied its physicochemical properties. As a result, they discovered that the above antibiotic is a novel substance having distinct physicochemical characteristics and named it TKR2648.
The present invention, therefore, is directed, in the first aspect, to the novel antibiotic TKR2648 which is represented by the following chemical formula (I) or its pharmacologically acceptable salt.
The present invention is further directed, in the second aspect, to a method of producing the novel antibiotic TKR2648 which comprises culturing a strain of microorganism belonging to the genus Penicillium and capable of elaborating said antibiotic TKR2648 and isolating said substance from the resulting culture broth.
In the third aspect, the present invention is directed to a microorganism belonging to the genus Penicillium and capable of producing the antibiotic TKR2648.


REFERENCES:
patent: 3954972 (1976-05-01), Michel et al.
patent: 4668627 (1987-05-01), Ohsugi et al.
patent: 59-017989 (1984-01-01), None
Ellestad et al., J. Org. Chem., 37:2045-2047, 1972.*
J. Chem. Soc. Perkin trans. (1981) vol. 1, No. 4 pp. 1173-1179; The Carbon-13 Nuclear Magnetic Resonance Spectra of Tetronate and 2-Pyrone Derivatives; Andrew Pelter et al.

Affiliated with

Also associated with

Rating

Antibiotic TKR2648 and process for producing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibiotic TKR2648 and process for producing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibiotic TKR2648 and process for producing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2551040