Antibiotic substances DC-45, and their use as medicaments

Details Antibiotic substances DC-45, and their use as medicaments Antibiotic substances DC-45, and their use as medicaments

1982-08-30

1985-04-16

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435169, 536 168, 536 181, A61K 3171, C07H 1526, C12P 1956

Patent

active

045115605

ABSTRACT:
New substances designated as DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 and represented by the following general formula: ##STR1## wherein (i) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR2## and R.sub.3 represents ##STR3## (designated DC-45-A); (ii) R.sub.1 represents --OH, R.sub.2 represents --CH.sub.2 OH and R.sub.3 represents ##STR4## (designated DC-45-B.sub.1); or (iii) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR5## and R.sub.3 represents ##STR6## (designated DC-45-B.sub.2). DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 possess antibiotic and anti-tumor activity and may be obtained by culturing a microorganism of the genus Streptomyces. Preferred strain is Streptomyces bottropensis (FERM-P No. 5219; NRRL 12051).

REFERENCES:
patent: 4393056 (1983-07-01), Tomita et al.
Brockman et al., "Chem. Abst." vol. 70, 1969, p. 97116(y).

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