Antibiotic purification process

Details Antibiotic purification process Antibiotic purification process

1978-06-28

1980-04-01

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D50102

Patent

active

041962850

ABSTRACT:
Cephamycin C is concentrated and purified by subjecting a fermentation broth which contains Cephamycin C to the following sequence of steps: filtration at acidic pH, passage through a methylene sulfonic acid cation ion exchange resin, washing with an aqueous stream having a low concentration of Cephamycin C, and elution using the above aqueous stream from the previous step, recirculated and maintained at an elevated pH.

REFERENCES:
patent: 3709880 (1973-01-01), Goegelman et al.
patent: 3983108 (1976-09-01), Bines

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